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首页> 外文期刊>Polymers >Biphasic Calcium Phosphate (BCP)-Immobilized Porous Poly (d,l-Lactic- co -Glycolic Acid) Microspheres Enhance Osteogenic Activities of Osteoblasts
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Biphasic Calcium Phosphate (BCP)-Immobilized Porous Poly (d,l-Lactic- co -Glycolic Acid) Microspheres Enhance Osteogenic Activities of Osteoblasts

机译：双相磷酸钙（BCP）固定化多孔聚（d，l-乳酸-乙醇酸）微球增强成骨细胞的成骨活性

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摘要

The purpose of this study was to evaluate the potential of porous poly (d,l-lactic- co -glycolic acid) (PLGA) microspheres (PMSs) immobilized on biphasic calcium phosphate nanoparticles (BCP NPs) (BCP-IM-PMSs) to enhance osteogenic activity. PMSs were fabricated using a fluidic device, and their surfaces were modified with l-lysine (aminated-PMSs), whereas the BCP NPs were modified with heparin–dopamine (Hep-DOPA) to obtain heparinized–BCP (Hep-BCP) NPs. BCP-IM-PMSs were fabricated via electrostatic interactions between the Hep-BCP NPs and aminated-PMSs. The fabricated BCP-IM-PMSs showed an interconnected pore structure. In vitro studies showed that MG-63 cells cultured on BCP-IM-PMSs had increased alkaline phosphatase activity, calcium content, and mRNA expression of osteocalcin (OCN) and osteopontin (OPN) compared with cells cultured on PMSs. These data suggest that BCP NP-immobilized PMSs have the potential to enhance osteogenic activity.
机译：这项研究的目的是评估固定在双相磷酸钙纳米颗粒（BCP NPs）（BCP-IM-PMSs）上的多孔聚（d，l-乳酸-乙醇酸）（PLGA）微球（PMS）的潜力。增强成骨活性。 PMS使用流体装置制造，其表面用l-赖氨酸（胺化PMS）修饰，而BCP NPs用肝素-多巴胺（Hep-DOPA）修饰以获得肝素化BCP（Hep-BCP）NP。 BCP-IM-PMS是通过Hep-BCP NP与胺化PMS之间的静电相互作用制造的。制成的BCP-IM-PMS显示出相互连接的孔结构。体外研究表明，与在PMS上培养的细胞相比，在BCP-IM-PMS上培养的MG-63细胞具有更高的碱性磷酸酶活性，钙含量以及骨钙素（OCN）和骨桥蛋白（OPN）的mRNA表达。这些数据表明，BCP NP固定的PMS具有增强成骨活性的潜力。

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