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首页> 外文期刊>Pathology oncology research: POR >The Expression of Notch 1 and Notch 3 in Gallbladder Cancer and Their Clinicopathological Significance
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The Expression of Notch 1 and Notch 3 in Gallbladder Cancer and Their Clinicopathological Significance

机译：Notch 1和Notch 3在胆囊癌中的表达及其临床病理意义

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id="Par1" class="Para">Gallbladder cancers (GBCs) are highly malignant gastrointestinal cancers. The biological makers for the prognosis and targeting therapy of GBCs have not been established. The protein expression of Notch 1 and Notch 3 in 46 squamous cell/adenosquamous carcinomas (SC/ASCs) and 80 adenocarcinomas (AC) was measured using immunohistochemistry. Positive Notch 1 and Notch 3 expression in both SC/ASC and AC was significantly associated with large tumor size, invasion, metastasis, and low surgical curability (P????0.05 or P????0.01). Univariate Kaplan-Meier analysis showed that positive Notch 1 and Notch 3 expression was significantly associated with mean survival of SC/ASC and AC patients (P????0.01 or P????0.001). Multivariate Cox regression analysis showed that positive Notch 1 and Notch 3 expression, as well as low differentiation, large tumor size, high TNM stage, invasion, lymph node metastasis, and surgical curability are independent poor-prognostic factors in both SC/ASC and AC patients. Positive Notch 1 and Notch 3 expression is closely correlated with severe clinicopathological characteristics and poor prognosis in both SC/ASC and AC patients.
机译：id =“ Par1” class =“ Para”>胆囊癌（GBC）是高度恶性的胃肠道癌。尚未建立用于GBC预后和靶向治疗的生物制剂。使用免疫组织化学方法检测46个鳞状细胞/腺鳞癌（SC / ASCs）和80个腺癌（AC）中Notch 1和Notch 3的蛋白表达。 SC / ASC和AC中Notch 1和Notch 3阳性表达与肿瘤大，浸润，转移和手术治愈率低显着相关（ P ?? 0.05或 P ?? P ?? <0.01或 P ??

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