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首页> 外文期刊>The British journal of psychiatry : >Functional connectivity and grey matter volume of the striatum in schizophrenia
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Functional connectivity and grey matter volume of the striatum in schizophrenia

机译：精神分裂症患者纹状体的功能连通性和灰质体积

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Background Alterations in the dopaminergic reward system, predominantly the striatum, constitute core characteristics of schizophrenia. Aims Functional connectivity of the dorsal striatum during reward-related trial-and-error learning was investigated in 17 people with schizophrenia and 18 healthy volunteers and related to striatal grey matter volume and psychopathology. Method We used voxel-based morphometry and psychophysiological interaction to examine striatal volume and connectivity. Results A reduced functional connectivity between left striatum and temporo-occipital areas, precuneus and insula could be detected in the schizophrenia group. The positive correlation between grey matter volume and functional connectivity of the left striatum yielded significant results in a very similar network. Connectivity of the left striatum was negatively correlated with negative symptoms. Conclusions Present results suggest a disruption in striatal functional connectivity that is closely linked to grey matter morphometry of the striatum. Decreased connectivity between the striatum and psychopathologically relevant networks may explain the emergence of negative symptoms.
机译：背景多巴胺能奖励系统（主要是纹状体）的改变构成了精神分裂症的核心特征。目的在17名精神分裂症患者和18名健康志愿者中研究与奖励相关的试验和错误学习过程中背侧纹状体的功能连通性，这些功能性与纹状体灰质量和精神病理学有关。方法我们使用基于体素的形态计量学和心理生理学相互作用来检查纹状体的体积和连通性。结果精神分裂症患者的左纹状体与颞枕区，前突神经和孤立岛之间的功能连接性降低。在非常相似的网络中，灰质体积与左纹状体功能连通性之间的正相关性产生了显着结果。左纹状体的连通性与阴性症状呈负相关。结论目前的结果表明，纹状体功能连接的破坏与纹状体的灰质形态密切相关。纹状体与心理病理相关网络之间的连通性降低可能解释了不良症状的出现。

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