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首页> 外文期刊>The British journal of psychiatry : >Schizophrenia and the frontal lobes
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Schizophrenia and the frontal lobes

机译：精神分裂症和额叶

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Background It has been suggested that there is frontal lobe involvement in schizophrenia, and that it may be lateralised and gender-specific. Aims To clarify the structure of the frontal lobes in schizophrenia in a post-mortem series. Method The volume of white matter and cortical components of the frontal lobes was measured in brains of controls and patients with schizophrenia using planimetry and the Cavalieri principle. The components measured were: superior frontal gyrus, middle frontal gyrus, a composite of inferior frontal gyrus and orbito-frontal cortex, as well as total frontal lobe cortex and white matter. In addition, the anterior cingulate gyrus was measured. Results No diagnosis, gender, diagnosis ?— side, diagnosis ?— gender or diagnosis ?— gender ?— side interactions were observed in the volume of any of the components, the grey matter as a whole or the white matter. No evidence for volumetric inter-group differences was found for the anterior cingulate gyrus. Conclusions Such structural abnormalities as are present in the frontal lobes are more subtle than straightforward alterations in tissue volume; they may include changes in shape and the pattern of gyral folding.
机译：背景研究表明，精神分裂症患者存在额叶受累，可能是偏侧性和性别特异性。目的在验尸系列中阐明精神分裂症额叶的结构。方法采用平面法和卡瓦列利原理，测定对照组和精神分裂症患者大脑中白质和额叶皮质成分的含量。测量的成分是：额额上回，额额中下，额额下回和眶额皮质的复合体，以及额叶总皮层和白质。另外，测量了前扣带回。结果在任何成分的体积，整体灰质或白质的体积中均未观察到诊断，性别，诊断，副反应，诊断或性别副反应。没有发现前扣带回的体积间差异的证据。结论额叶中存在的这种结构异常比组织体积的直接改变更为微妙。它们可能包括形状变化和回旋折叠的样式。

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