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Therapeutic aspects of cannabis and cannabinoids

机译：大麻和大麻素的治疗方面

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Background Review commissioned in 1996 by the Department of Health (DOH). Aims Assess therapeutic profile of cannabis and cannabinoids. Method Medline search, references supplied by DOH and others, and personal communications. Results and Conclusions Cannabis and some cannabinoids are effective anti-emetics and analgesics and reduce intra-ocular pressure. There is evidence of symptom relief and improved well-being in selected neurological conditions, AIDS and certain cancers. Cannabinoids may reduce anxiety and improve sleep. Anticonvulsant activity requires clarification. Other properties identified by basic research await evaluation. Standard treatments for many relevant disorders are unsatisfactory. Cannabis is safe in overdose but often produces unwanted effects, typically sedation, intoxication, clumsiness, dizziness, dry mouth, lowered blood pressure or increased heart rate. The discovery of specific receptors and natural ligands may lead to drug developments. Research is needed to optimise dose and route of administration, quantify therapeutic and adverse effects, and examine interactions.
机译：由卫生署（DOH）于1996年委托进行的背景审查。目的评估大麻和大麻素的治疗概况。方法Medline搜索，DOH等提供的参考资料以及个人通讯。结果与结论大麻和一些大麻素是有效的止吐药和止痛药，可降低眼内压。有证据表明，在某些神经系统疾病，艾滋病和某些癌症中，症状可缓解且幸福感得到改善。大麻素可减少焦虑症并改善睡眠。抗惊厥活性需要澄清。基础研究确定的其他属性有待评估。许多相关疾病的标准治疗均不能令人满意。服用过量的大麻是安全的，但通常会产生不良影响，通常是镇静，中毒，笨拙，头晕，口干，血压降低或心跳加快。特定受体和天然配体的发现可能导致药物开发。需要进行研究以优化给药剂量和途径，量化治疗和不良反应以及检查相互作用。

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