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首页> 外文期刊>The British journal of psychiatry : >Neurodevelopmental indices and the development of psychotic symptoms in subjects at high risk of schizophrenia
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Neurodevelopmental indices and the development of psychotic symptoms in subjects at high risk of schizophrenia

机译：精神分裂症高危人群的神经发育指标和精神症状的发展

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Background Neurological a€?soft signsa€? and minor physical anomalies (MPAs) are reported to be more frequent in patients with schizophrenia than in controls. Aims To determine whether these disturbances are genetically mediated, and whether they are central to the genesis of symptoms or epiphenomena. Method We obtained ratings in 152 individuals who were antipsychotic drug-free and at high risk, some of whom had experienced psychotic symptoms, as well as 30 first-episode patients and 35 healthy subjects. Results MPAs and Neurological Evaluation Scale (NES) a€?sensory integration abnormalitiesa€? were more frequent in high-risk subjects than in healthy controls, but there were no reliable differences between high-risk subjects with and without psychotic symptoms. MPAs were most frequent in high-risk subjects with least genetic liability and NES scores showed no genetic associations. Conclusions The lack of associations with psychotic symptoms and genetic liability to schizophrenia suggests that soft signs and physical anomalies are nonspecific markers of developmental deviance that are not mediated by the gene(s) for schizophrenia.
机译：背景神经系统软迹象据报道，精神分裂症患者的轻度和轻度身体异常（MPA）频率高于对照组。目的确定这些障碍是否是遗传介导的，以及它们是否是症状或表观现象的起源。方法我们获得了152例无抗精神病药物且高风险，其中一些患者有精神病症状的患者以及30例首发患者和35例健康受试者的评分。结果MPA和神经系统评估量表（NES）涉及感觉统合异常。高风险受试者的患病率高于健康对照组，但有无精神病症状的高风险受试者之间没有可靠的差异。 MPA在高遗传风险人群中频率最高，遗传责任最少，而NES分数显示无遗传关联。结论缺乏与精神病症状和精神分裂症遗传遗传的关联性，表明软体征和身体异常是发育异常的非特异性标志物，并非由精神分裂症基因介导。

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