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首页> 外文期刊>The British journal of psychiatry : >Immune signatures and disorder-specific patterns in a cross-disorder gene expression analysis
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Immune signatures and disorder-specific patterns in a cross-disorder gene expression analysis

机译：跨疾病基因表达分析中的免疫特征和特定疾病模式

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Background Recent studies point to overlap between neuropsychiatric disorders in symptomatology and genetic aetiology. Aims To systematically investigate genomics overlap between childhood and adult attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and major depressive disorder (MDD). Method Analysis of whole-genome blood gene expression and genetic risk scores of 318 individuals. Participants included individuals affected with adult ADHD ( n = 93), childhood ADHD ( n = 17), MDD ( n = 63), ASD ( n = 51), childhood dual diagnosis of ADHDa€“ASD ( n = 16) and healthy controls ( n = 78). Results Weighted gene co-expression analysis results reveal disorder-specific signatures for childhood ADHD and MDD, and also highlight two immune-related gene co-expression modules correlating inversely with MDD and adult ADHD disease status. We find no significant relationship between polygenic risk scores and gene expression signatures. Conclusions Our results reveal disorder overlap and specificity at the genetic and gene expression level. They suggest new pathways contributing to distinct pathophysiology in psychiatric disorders and shed light on potential shared genomic risk factors.
机译：背景技术最近的研究表明，症状和遗传病因的神经精神疾病之间存在重叠。目的系统研究儿童与成人注意缺陷多动障碍（ADHD），自闭症谱系障碍（ASD）和重度抑郁症（MDD）之间的基因组学重叠。方法分析318人的全基因组血液基因表达和遗传风险评分。参加者包括受成人ADHD（n = 93），儿童ADHD（n = 17），MDD（n = 63），ASD（n = 51），儿童ADHD双重诊断（A = 16）和健康的个体控制项（n = 78）。结果加权基因共表达分析结果揭示了儿童ADHD和MDD的特定疾病特征，并突出显示了与MDD和成人ADHD病情成反比的两个免疫相关基因共表达模块。我们发现多基因风险评分和基因表达特征之间没有显着关系。结论我们的结果揭示了在遗传和基因表达水平上的疾病重叠和特异性。他们提出了有助于精神疾病独特病理生理的新途径，并揭示了潜在的共同基因组危险因素。

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