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首页> 外文期刊>The British journal of psychiatry : >Non-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders
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Non-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders

机译：5HTTLPR和对儿童焦虑症的心理治疗反应之间的联系没有重复

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Background We previously reported an association between 5HTTLPR genotype and outcome following cognitivea€“behavioural therapy (CBT) in child anxiety (Cohort 1). Children homozygous for the low-expression short-allele showed more positive outcomes. Other similar studies have produced mixed results, with most reporting no association between genotype and CBT outcome. Aims To replicate the association between 5HTTLPR and CBT outcome in child anxiety from the Genes for Treatment study (GxT Cohort 2, n = 829). Method Logistic and linear mixed effects models were used to examine the relationship between 5HTTLPR and CBT outcomes. Mega-analyses using both cohorts were performed. Results There was no significant effect of 5HTTLPR on CBT outcomes in Cohort 2. Mega-analyses identified a significant association between 5HTTLPR and remission from all anxiety disorders at follow-up (odds ratio 0.45, P = 0.014), but not primary anxiety disorder outcomes. Conclusions The association between 5HTTLPR genotype and CBT outcome did not replicate. Short-allele homozygotes showed more positive treatment outcomes, but with small, non-significant effects. Future studies would benefit from utilising whole genome approaches and large, homogenous samples.
机译：背景我们先前曾报道5HTTLPR基因型与儿童焦虑症的认知行为治疗（CBT）后的结局之间存在关联（队列1）。低表达短等位基因纯合子的儿童显示出更多的积极结果。其他类似的研究也得出了不同的结果，大多数报道基因型和CBT结果之间没有关联。目的从基因治疗研究中复制5HTTLPR和CBT结果对儿童焦虑症的关联（GxT队列2，n = 829）。方法采用Logistic和线性混合效应模型检验5HTTLPR和CBT结果之间的关系。使用这两个队列进行了大型分析。结果队列2中5HTTLPR对CBT结局无显着影响。大规模分析发现5HTTLPR与随访时所有焦虑症的缓解之间存在显着相关性（几率0.45，P = 0.014），但原发性焦虑症结局无统计学意义。 。结论5HTTLPR基因型与CBT结局之间没有关联。短等位基因纯合子显示出更积极的治疗结果，但效果不明显。未来的研究将受益于利用全基因组方法和大而均匀的样本。

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