Alzheimer's disease: the amyloid hypothesis on trial

Judith R. Harrison; Michael J. Owen

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Alzheimer's disease: the amyloid hypothesis on trial

机译：阿尔茨海默氏病：试验中的淀粉样假说

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The pathogenesis of Alzheimer's disease is complex. The amyloid hypothesis has directed research efforts for many years, but it has recently been questioned after failed drug trials. Here, we review the evidence for and against and suggest that it might be premature to abandon the amyloid hypothesis.

机译：阿尔茨海默氏病的发病机理很复杂。淀粉样蛋白假说已经指导了很多年的研究工作，但是最近在药物试验失败后受到了质疑。在这里，我们回顾了支持和反对的证据，并提出放弃淀粉样假说可能为时过早。

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《The British journal of psychiatry :》 |2016年第1期|共页
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Judith R. Harrison; Michael J. Owen;
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1. Structure and location of amyloid beta peptide chains and arrays in Alzheimer's disease: new findings require reevaluation of the amyloid hypothesis and of tests of the hypothesis. [J] . Rosenblum WI, ol.com Neurobiology of Aging: Experimental and Clinical Research . 2002,第2期

机译：淀粉样蛋白β肽链和阵列在阿尔茨海默氏病中的结构和位置：新发现要求重新评估淀粉样蛋白假说和假说的检验。
2. Major Clinical Trials Failed the Amyloid Hypothesis of Alzheimer's Disease [J] . Huang Yan‐Mei, Shen Jian, Zhao Hai‐Lu Journal of the American Geriatrics Society . 2019,第4期

机译：主要临床试验失败了阿尔茨海默病的淀粉样蛋白假说
3. A good marker does not mean a good target for clinical trials in Alzheimer's disease: the amyloid hypothesis questioned [J] . Pedro Modrego, Antonio Lobo Neurodegenerative disease management . 2019,第3期

机译：一个良好的标记并不意味着阿尔茨海默病患者临床试验的良好目标：淀粉样蛋白假设质疑
4. Deep Learning-Based Estimation of Non-Specific Uptake in Amyloid-PET Images from Structural MRI for Improved Quantification of Amyloid Load in Alzheimer's Disease [C] . Haohui Liu, Ying-Hwey Nai, Christopher Chen, IEEE International Symposium on Computer-Based Medical Systems . 2020

机译：基于深度学习的结构性MRI对非特异性摄取淀粉样PET图像的估计，以改善量化阿尔茨海默氏病的淀粉样负荷
5. Cystatin C Amyloid Mechanism, Interaction with Amyloid-Beta, and Regulatory Implications for Alzheimer's Disease [D] . Perlenfein, Tyler John. 2017

机译：胱抑素C淀粉样蛋白的机制，与淀粉样蛋白β的相互作用，以及对阿尔茨海默氏病的调控意义
6. Cross-interactions between the Alzheimer disease amyloid-β peptide and other amyloid proteins. A FURTHER ASPECT OF THE AMYLOID CASCADE HYPOTHESIS. [O] . Jinghui Luo, Sebastian K. T. S. Wärmländer, Astrid Gräslund, 2017

机译：阿尔茨海默氏病淀粉样β肽与其他淀粉样蛋白之间的交叉相互作用。淀粉级联反应假说的另一个方面。
7. Cross-interactions between the Alzheimer Disease Amyloid-β Peptide and Other Amyloid Proteins: A Further Aspect of the Amyloid Cascade Hypothesis [O] . Luo, Jinghui, Wärmländer, Sebastian K. T. S., Gräslund, Astrid, 2016

机译：阿尔茨海默病淀粉样蛋白β肽与其他淀粉样蛋白之间的交叉相互作用：淀粉样蛋白级联假说的另一个方面

Alzheimer's disease: the amyloid hypothesis on trial

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