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首页> 外文期刊>The British journal of psychiatry : >Executive dysfunction in first-episode schizophrenia and relationship to duration of untreated psychosis: the West London Study
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Executive dysfunction in first-episode schizophrenia and relationship to duration of untreated psychosis: the West London Study

机译：首发精神分裂症的执行功能障碍及其与未治疗的精神病持续时间的关系：西伦敦研究

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Background Many studies have demonstrated early generalised cognitive impairment in schizophrenia. Aims To examine executive function in first-episode schizophrenia, characterise the nature of the impairment and specify any relationships with symptoms and duration of untreated psychosis (DUP). Method Patients ( n =136) and normal controls ( n =81) were assessed with the Cambridge Automated Neuropsychological Test Battery, National Adult Reading Test IQ, and Scales for the Assessment of Positive and Negative Symptoms. Results Memory and executive impairments in patients were independent of IQ level. Spatial working memory was impaired because of inadequate strategy use. On a planning task, patients showed reduced planning times and suboptimal problem-solving. On an attentional set-shifting task, 75% of patients were able to perform an extra-dimensional shift thought to be a core attribute of prefrontal cortex function. Those who failed had significantly longer DUP. Conclusions Prefrontal cortex function deteriorates at the onset of psychosis and continues to worsen over time.
机译：背景许多研究表明，精神分裂症的早期普遍性认知障碍。目的要检查首发精神分裂症的执行功能，表征损伤的性质，并指明与症状和未经治疗的精神病（DUP）持续时间的任何关系。方法用剑桥自动神经心理测验仪，全国成人阅读测验智商和用于评估阳性和阴性症状的量表对患者（n = 136）和正常对照（n = 81）进行评估。结果患者的记忆力和执行力障碍与智商水平无关。空间工作记忆因策略使用不足而受损。在计划任务中，患者表现出减少的计划时间和次优的问题解决能力。在一项注意力转移任务上，有75％的患者能够进行维度外转移，这是前额叶皮层功能的核心属性。那些失败的人具有更长的DUP。结论精神病发作前额叶皮层功能恶化，并随着时间的推移继续恶化。

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