• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The British journal of psychiatry : >Temporal lobe volume changes in people at high risk of schizophrenia with psychotic symptoms
【24h】

Temporal lobe volume changes in people at high risk of schizophrenia with psychotic symptoms

机译：具有精神病症状的精神分裂症高风险人群的颞叶容量变化

获取原文
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Magnetic resonance imaging (MRI) has demonstrated abnormalities of brain structure, particularly of the temporal lobes, in schizophrenia. These are thought to be neurodevelopmental in origin, but when they become evident is unknown. Aims To determine if temporal lobe volumes reduce during the development of symptoms of schizophrenia in initially well people at high risk of this disorder. Method A group of 66 people who had at least two first- or second-degree relatives with schizophrenia and a control group of 20 healthy people had a structural MRI scan of the whole brain which was repeated after approximately 2 years. Regions of interest, specifically the amygdalaa€”hippocampus complex and the temporal lobes, were traced semi-automatically by three masked raters with good inter-and intrarater reliability. Results Regional brain volume changes over 2 years did not differ between high-risk and healthy participants. Within the high-risk group, the 19 people with psychotic symptoms (12 at first assessment) had a mean reduction of 2163 mm3 in the right temporal lobe compared with 97 mm3 in the 47 without symptoms ( P =0.02). Conclusions Our findings suggest that people at high risk of schizophrenia with psychotic symptoms show reductions in temporal lobe volumes.
机译：背景技术磁共振成像（MRI）已证明精神分裂症的大脑结构异常，尤其是颞叶异常。这些被认为是神经发育的起源，但是何时变得明显尚不清楚。目的确定在患有精神分裂症的高风险人群中，精神分裂症症状发展过程中颞叶体积是否减少。方法：一组由至少两个精神分裂症的一级或二级亲属组成的66人组成，一组由20个健康人组成的对照组，对整个大脑进行结构MRI扫描，并在大约2年后重复进行。感兴趣的区域，特别是扁桃体海马复合体和颞叶，由三个具有良好的内部和评估者可靠性的蒙版评估者半自动追踪。结果高风险参与者和健康参与者在2年内的区域脑容量变化没有差异。在高危人群中，有19例有精神病症状的人（初次评估为12例）右颞叶平均减少2163 mm3，而47例无症状者为97 mm3（P = 0.02）。结论我们的发现表明，患有精神病症状的精神分裂症高危人群的颞叶容量减少。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号