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Venlafaxine extended release (ER) in the treatment of generalised anxiety disorder

机译:文拉法辛缓释(ER)治疗广泛性焦虑症

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Background Generalised anxiety disorder (GAD) has received less study than other anxiety disorders, particularly its long-term treatment. Aims To assess the efficacy and safety of venlafaxine extended release (ER) in patients with GAD. Method A total of 541 out-patients, 18-86 years old, were recruited to this 24-week, placebo-controlled, double-blind study of three fixed doses (37.5, 75 and 150 mg/day) of venlafaxine ER. Results All doses of venlafaxine ER showed efficacy superior to placebo, apparent from week 2, that was sustained throughout the 24-week study for the two higher doses. The discontinuation rate did not differ significantly among the treatment groups. Conclusions Venlafaxine ER is an effective and safe treatment for GAD for up to 6 months.
机译:背景技术广泛性焦虑症(GAD)的研究少于其他焦虑症,尤其是其长期治疗。目的评估文拉法辛缓释(ER)在GAD患者中的疗效和安全性。方法总共541名18-86岁的门诊患者参加了这项为期24周的安慰剂对照双盲研究,研究了三种固定剂量(37.5、75和150 mg /天)的文拉法辛ER。结果从第2周开始,所有剂量的文拉法辛ER均显示出优于安慰剂的功效,并在整个24周研究中持续了两次高剂量。各治疗组间的停药率无明显差异。结论Venlafaxine ER可以有效且安全地治疗GAD长达6个月。

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