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Intellectual asymmetry and genetic liability in first-degree relatives of probands with schizophrenia

机译:精神分裂症先证者一级亲属的智力不对称和遗传责任

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Summary Intellectual asymmetry with superiority of verbal skills to spatial skills frequently characterises patients with schizophrenia, but it is unclear whether this pattern also reflects genetic susceptibility tothe disorder. We examined the association of a continuous measure of genetic liability to schizophrenia with Verbala€“Spatial Contrast IQ (an index of intellectual asymmetry) in108 first-degree relatives without psychosis of probands with schizophrenia. Higher genetic liability was significantly associated with greater intellectual asymmetry in favour of verbal skills. Intellectual asymmetry with a relative superiority of verbal skills to spatial skills represents a putative endophenotype of schizophrenia.
机译:总结智力不对称具有语言技能优于空间技能的特点,通常是精神分裂症患者的特征,但尚不清楚这种模式是否也反映了该疾病的遗传易感性。我们检查了108名没有精神分裂症先证者精神病的一级亲属中对精神分裂症的遗传责任的连续测量与“空间对比智商(智力不对称指数)”的关联。更高的遗传责任感与更大的智力不对称显着相关,有利于口头表达能力。智力不对称具有相对于空间技能而言的口头表达能力优势,这代表了精神分裂症的一种内在表型。

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