...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The British journal of psychiatry : >Neuroanatomical correlates of different vulnerability states for psychosis and their clinical outcomes
【24h】

Neuroanatomical correlates of different vulnerability states for psychosis and their clinical outcomes

机译：精神病的不同脆弱性状态的神经解剖相关性及其临床结果

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Structural brain abnormalities have been described in individuals with an at-risk mental state for psychosis. However, the neuroanatomical underpinnings of the early and late at-risk mental state relative to clinical outcome remain unclear. Aims To investigate grey matter volume abnormalities in participants in a putatively early or late at-risk mental state relative to their prospective clinical outcome. Method Voxel-based morphometry of magnetic resonance imaging data from 20 people with a putatively early at-risk mental state (ARMSa€“E group) and 26 people with a late at-risk mental state (ARMSa€“L group) as well as from 15 participants with at-risk mental states with subsequent disease transition (ARMSa€“T group) and 18 participants without subsequent disease transition (ARMSa€“NT group) were compared with 75 healthy volunteers. Results Compared with healthy controls, ARMSa€“L participants had grey matter volume losses in frontotemporolimbic structures. Participants in the ARMSa€“E group showed bilateral temporolimbic alterations and subtle prefrontal abnormalities. Participants in the ARMSa€“T group had prefrontal alterations relative to those in the ARMSa€“NT group and in the healthy controls that overlapped with the findings in the ARMSa€“L group. Conclusions Brain alterations associated with the early at-risk mental state may relate to an elevated susceptibility to psychosis, whereas alterations underlying the late at-risk mental state may indicate a subsequent transition to psychosis.
机译：背景技术已经在患有精神病的处于高风险精神状态的个体中描述了结构性脑异常。然而，相对于临床结果而言，早期和晚期高危精神状态的神经解剖学基础仍然不清楚。目的研究相对于他们预期的临床结局而言，处于早期或晚期高风险精神状态的参与者的灰质体积异常。方法基于Voxel的磁共振成像数据的形态计量学，该数据来自20名潜在的早期处于危险状态的心理状态（ARMSa€“ E”组）和26个晚期危险的处于精神状态（ARMSa€“ L”级）以及将15名具有高危心理状态并随后发生疾病转移的参与者（ARMSa？T组）和18名无随后疾病后转移的参与者（ARMSa？NT组）与75名健康志愿者进行了比较。结果与健康对照组相比，ARMSa€™参与者的额颞睑结构中灰质体积减少。 ARMSa€™组的参与者表现出双侧颞下颌骨改变和细微的前额叶异常。相对于ARMSaNT组和健康对照组，ARMSaTT组的参与者前额叶改变与ARMSa€L组的发现相重叠。结论与早期处于高风险状态的精神状态相关的脑部改变可能与较高的精神病易感性有关，而在处于晚期处于高风险状态的精神状态的基础性变化可能预示着随后的向精神病的过渡。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号