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首页> 外文期刊>The British journal of psychiatry : >Interhemispheric asymmetry of motor cortical excitability in major depression as measured by transcranial magnetic stimulation
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Interhemispheric asymmetry of motor cortical excitability in major depression as measured by transcranial magnetic stimulation

机译：经颅磁刺激测量大抑郁症运动皮层兴奋性的半球不对称性

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Background Neuroimaging studies of major depressive disorder (MDD) indicate interhemispheric differences in prefrontal cortical activity (right greater than left). Aims To investigate whether there are any interhemispheric differences of motor cortical excitability in MDD. Method Eight patients with treatment-refractory MDD off medication were assessed for the severity of their depression, and transcranial magnetic stimulation studies (bilateral motor threshold and paired-pulse studies) were conducted. Eight normal controls were also studied. Results MDD patients showed significant interhemispheric differences in motor threshold and paired-pulse curves, both of which showed lower excitability on the left hemisphere. Such differences were absent in controls. Conclusions Our findings may aid the further understanding of the neurophysiology underlying MDD.
机译：对重大抑郁症（MDD）的背景神经影像学研究表明前额叶皮质活动的半球间差异（右大于左）。目的探讨MDD中运动皮层兴奋性的半球间差异。方法对8例接受难治性MDD药物治疗的患者的抑郁程度进行评估，并进行经颅磁刺激研究（双侧运动阈值和成对脉冲研究）。还研究了八个正常对照。结果MDD患者在运动阈值和成对脉冲曲线上表现出明显的半球间差异，两者在左半球的兴奋性均较低。对照中没有这种差异。结论我们的发现可能有助于进一步了解MDD背后的神经生理学。

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