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首页> 外文期刊>The British journal of psychiatry : >Effect of antidepressive therapy on retinal contrast processing in depressive disorder
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Effect of antidepressive therapy on retinal contrast processing in depressive disorder

机译：抗抑郁疗法对抑郁症患者视网膜造影过程的影响

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Background Recently, we reported a reduced retinal contrast gain in unmedicated and medicated patients with major depression. Aims To analyse whether the contrast gain normalises after successful antidepressive therapy by recording the pattern electroretinogram (PERG) in healthy controls and patients with depression before and after antidepressive therapy. Method Fourteen patients diagnosed with major depression were repeatedly scanned and the results compared with that from 40 matched controls. Results The retinal contrast gain was lower at baseline in patients with depression, was normalised with remission and correlated with the severity of depression. Patients who did not achieve remission retained significantly lower contrast gain at follow-up. Conclusions The study provides evidence for a state-dependent modulation of retinal contrast gain in patients with major depression. Reduced contrast gain normalised after therapy. A PERG-based contrast gain could serve as a state marker of depression.
机译：背景技术最近，我们报道了患有严重抑郁症的未经药物治疗和药物治疗的患者视网膜对比度增加减少。目的通过记录健康对照和抑郁症患者抗抑郁治疗前后的心电图视网膜电图（PERG），分析抗抑郁治疗成功后对比度增强是否正常。方法对14例被诊断为重度抑郁症的患者进行反复扫描，并将结果与​​40例相匹配的对照组进行比较。结果抑郁症患者的视网膜对比度增加在基线时较低，已通过缓解得以恢复并与抑郁症的严重程度相关。未获得缓解的患者在随访时保留明显较低的对比增益。结论该研究为重度抑郁症患者的视网膜对比增益的状态依赖性调节提供了证据。降低的对比增益在治疗后恢复正常。基于PERG的对比增益可作为抑郁状态的标志。

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