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首页> 外文期刊>The British journal of psychiatry : >Metabolic disturbance in first-episode schizophrenia
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Metabolic disturbance in first-episode schizophrenia

机译：首发精神分裂症的代谢紊乱

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Background Schizophrenia shortens life, e.g. through suicide and obesity-related diseases such as type 2 diabetes mellitus. It is assumed that medications play a major role, but most of the evidence for this comes from studies poorly controlled for variables such as lifestyle and medication status. Aims To determine whether schizophrenia is associated (independently of medication) with the development of certain metabolic disturbances and whether these might be explained by stress axis dysfunction. Method Literature review. Results Most studies did not control for confounding factors such as previous usage of medication, lifestyle, age and ethnicity. A few conducted in drug-na?ˉve patients with first-episode schizophrenia appear to indicate that these patients have higher than expected rates of visceral obesity and impaired fasting glucose concentrations, which may be related to a subtle disturbance of the hypothalamica€“pituitarya€“adrenal axis. Conclusions Schizophrenia is independently associated with physical illnesses that have a metabolic signature. Therefore, patients need to have a thorough physical assessment at diagnosis and at regular intervals thereafter. Metabolic disturbances have been found in drug-na?ˉve patients with first-episode illness and may be an inherent part of the illness.
机译：背景精神分裂症会缩短寿命，例如通过自杀和肥胖相关疾病，例如2型糖尿病。假设药物起着主要作用，但是大多数证据来自对生活方式和药物状态等变量控制不力的研究。目的确定精神分裂症是否与某些代谢紊乱的发生有关（独立于药物治疗），以及是否可以通过应力轴功能障碍来解释。方法文献复习。结果大多数研究并未控制混杂因素，例如以前的药物使用，生活方式，年龄和种族。在未曾接受过药物治疗的首发精神分裂症患者中进行的一些研究似乎表明，这些患者的内脏肥胖率高于预期，并且空腹血糖浓度受损，这可能与下丘脑下垂体的细微障碍有关。肾上腺轴。结论精神分裂症与具有代谢特征的身体疾病独立相关。因此，患者需要在诊断时及之后定期进行全面的身体评估。在初次发病的初次吸毒的初次患者中发现了代谢紊乱，这可能是疾病的固有部分。

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