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Outcome measures in early psychosis

机译：早期精神病的治疗措施

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Background Duration of untreated psychosis (DUP) is considered an important predictor of short-term clinical outcome. Aims To explore the evolution of the concept of DUP, synthesise the evidence for its predictive value, highlight the problems in measurement, and consider the potential pitfalls of using DUP as a measure of the effectiveness of early intervention services. Method A survey of recent literature was conducted. Results Several studies and two systematic reviews confirm that DUP has a robust but moderate effect on outcome in schizophrenia. Studies vary widely in how DUP is defined and measured, since identifying precise time points when psychosis emerges and remits is conceptually ambiguous and clinically difficult. Conclusions Standardised measurement of DUP is a vital first step in allowing comparisons between studies. Duration of untreated psychosis is a relevant measure only of the early detection function of early intervention services.
机译：背景未经治疗的精神病（DUP）的持续时间被认为是短期临床预后的重要预测指标。目的探索DUP概念的演变，综合其预测价值的证据，强调测量中的问题，并考虑将DUP用作衡量早期干预服务有效性的潜在陷阱。方法对近期文献进行调查。结果几项研究和两项系统评价证实，DUP对精神分裂症的结局具有强大而中等的作用。关于DUP的定义和测量方法的研究存在很大差异，因为确定精神病发作和缓解的确切时间点在概念上是模棱两可的，并且在临床上很困难。结论DUP的标准化测量是进行研究之间比较的至关重要的第一步。未经治疗的精神病的持续时间仅与早期干预服务的早期发现功能有关。

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