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首页> 外文期刊>The British journal of psychiatry : >Acute effects of treatment for prodromal symptoms for people putatively in a late initial prodromal state of psychosis
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Acute effects of treatment for prodromal symptoms for people putatively in a late initial prodromal state of psychosis

机译：最初处于晚期精神病性精神状态的人的前驱症状治疗的急性影响

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Background People in a putatively late prodromal state not only have an enhanced risk for psychosis but already suffer from mental and functional disturbances. Aims To evaluate the acute effects of a combined supportive and antipsychotic treatment on prodromal symptoms. Method Putatively prodromal individuals were randomly assigned to a needs-focused intervention without ( n =59) or with amisulpride ( n =65). Outcome measures at 12-weeks effects were prodromal symptoms, global functioning and extrapyramidal side-effects. Results Amisulpride plus the needs-focused intervention produced superior effects on attenuated and full-blown psychotic symptoms, basic, depressive and negative symptoms, and global functioning. Main side-effects were prolactin associated. Conclusions Coadministration of amisulpride yielded a marked symptomatic benefit. Effects require confirmation by a placebo-controlled study.
机译：背景技术前驱状态处于晚期的人不仅患有精神病的风险增加，而且已经患有精神和功能障碍。目的评估联合支持和抗精神病治疗对前驱症状的急性作用。方法将前驱个体随机分配至以需求为中心的干预，不使用（n = 59）或使用氨磺必利（n = 65）。在12周时的疗效指标为前驱症状，整体功能和锥体外系副作用。结果氨磺必利和针对需求的干预措施对减轻和全面出现的精神病症状，基本，抑郁和阴性症状以及整体功能产生了卓越的效果。主要副作用是催乳激素相关。结论氨磺必利的共同给药产生明显的症状改善。效果需要通过安慰剂对照研究来确认。

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