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首页> 外文期刊>The British journal of psychiatry : >Neural responses to dynamic multimodal stimuli and pathology-specific impairments of social cognition in schizophrenia and depression
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Neural responses to dynamic multimodal stimuli and pathology-specific impairments of social cognition in schizophrenia and depression

机译：精神分裂症和抑郁症中对动态多峰刺激和特定于病理的社会认知障碍的神经反应

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Background Individuals with schizophrenia and people with depression both show abnormal behavioural and neural responses when perceiving and responding to emotional stimuli, but pathology-specific differences and commonalities remain mostly unclear. Aims To directly compare empathic responses to dynamic multimodal emotional stimuli in a group with schizophrenia and a group with depression, and to investigate their neural correlates using functional magnetic resonance imaging (fMRI). Method The schizophrenia group ( n = 20), the depression group ( n = 24) and a control group ( n = 24) were presented with portrait-shot video clips expressing emotion through three possible communication channels: facial expression, prosody and content. Participants rated their own and the actora€?s emotional state as an index of empathy. Results Although no group differences were found in empathy ratings, characteristic differences emerged in the fMRI activation patterns. The schizophrenia group demonstrated aberrant activation patterns during the neutral speech content condition in regions implicated in multimodal integration and formation of semantic constructs. Those in the depression group were most affected during conditions with trimodal emotional and trimodal neutral stimuli, in key regions of the mentalising network. Conclusions Our findings reveal characteristic differences in patients with schizophrenia compared with those with depression in their cortical responses to dynamic affective stimuli. These differences indicate that impairments in responding to emotional stimuli may be caused by pathology-specific problems in social cognition.
机译：背景精神分裂症患者和抑郁症患者在感知和响应情绪刺激时均表现出异常的行为和神经反应，但是病理学上的差异和共性仍不清楚。目的直接比较精神分裂症组和抑郁症组对动态多模态情绪刺激的共情反应，并使用功能磁共振成像（fMRI）研究其神经相关性。方法向精神分裂症组（n = 20），抑郁症组（n = 24）和对照组（n = 24）提供通过面部表情，韵律和内容三个可能的沟通渠道表达情感的肖像录像片段。参与者将自己和演员的情感状态作为同情的指数。结果尽管在共情评价中未发现组差异，但功能磁共振成像激活模式中出现了特征差异。精神分裂症小组在中性语音内容条件期间在涉及多模式整合和语义结构形成的区域表现出异常的激活模式。在心理网络的关键区域，患有三峰情感和三峰中性刺激的抑郁症患者受到的影响最大。结论我们的发现揭示了精神分裂症患者与抑郁患者相比，其对动态情感刺激的皮质反应具有特征差异。这些差异表明，对情绪刺激的反应障碍可能是社会认知中特定于病理的问题引起的。

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