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首页> 外文期刊>The British journal of psychiatry : >Family history of psychiatric disorders and age at first contact in schizophrenia: an epidemiological study
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Family history of psychiatric disorders and age at first contact in schizophrenia: an epidemiological study

机译：精神疾病的家族病史和首次接触精神分裂症的年龄：一项流行病学研究

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Background The risk for schizophrenia has been associated with a family history of this and other psychiatric disorders. The relationship between age at first contact and family history of psychiatric illness is not certain. Aims To estimate the risks for schizophrenia associated with a range of psychiatric diagnoses in family members and to investigate the relationship between these risks and age at first contact for schizophrenia. Method A nested casea€”control study design was employed. Psychiatric admission data and socio-economic data were available for 7704 cases admitted between 1981 and 1998 in Denmark, 192 590 gender- and age-matched controls, and for the parents and siblings of all subjects. Results Controlling for socio-economic factors, risk for schizophrenia was associated with a family history of all psychiatric disorders except substance misuse and independently with a family history of suicide. The risk for schizophrenia associated with a family history of psychiatric disorders decreased as age at first contact increased. Conclusions Risk for schizophrenia is associated with a range of psychiatric disorders in family members and these risks are not constant across the risk period.
机译：背景精神分裂症的风险与该疾病和其他精神疾病的家族史有关。初次接触的年龄与精神病家族史之间的关系尚不确定。目的评估与家族成员进行一系列精神病诊断有关的精神分裂症的风险，并调查这些风险与首次接触精神分裂症的年龄之间的关系。方法采用巢式病例对照研究设计。可获得1981年至1998年在丹麦接受的7704例病例，192 590例年龄和性别相匹配的对照以及所有受试者的父母和兄弟姐妹的精神病学入院数据和社会经济数据。结果控制社会经济因素，精神分裂症的风险与除药物滥用外的所有精神疾病家族史有关，并与自杀家族史有关。随着第一次接触的年龄增加，与精神疾病家族史相关的精神分裂症的风险降低。结论精神分裂症的风险与家庭成员的一系列精神疾病有关，并且这些风险在整个风险期内并非恒定不变。

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