DRD3 gene and striatum in autism spectrum disorder

Marieke Langen; Sarah Durston; Sarai van Dijk; Vincent T. Mensen; Wouter G. Staal

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DRD3 gene and striatum in autism spectrum disorder

机译：自闭症谱系障碍中的DRD3基因和纹状体

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A single-nucleotide polymorphism (SNP) of the DRD3 gene (rs167771) was recently associated with autism spectrum disorders (ASD). Different polymorphisms of rs167771 corresponded to varying degrees of stereotyped behaviour. As DRD3 receptors are relatively overexpressed in the striatum, we investigated whether striatal volume was related to these polymorphisms in autism. We assessed volumes of caudate nucleus and putamen in 86 participants with ASD (mean age 15.3 years). MANCOVA showed an association between alleles of the rs167771 SNP and the volume of striatal structures. Furthermore, greater caudate nucleus volume correlated with stereotyped behaviour. These findings support a relationship between DRD3 gene SNPs, striatum and stereotyped behaviour in ASD.

机译：DRD3基因（rs167771）的单核苷酸多态性（SNP）最近与自闭症谱系障碍（ASD）相关。 rs167771的不同多态性对应于不同程度的刻板行为。由于DRD3受体在纹状体中相对过表达，因此我们调查了自闭症患者的纹状体体积是否与这些多态性有关。我们评估了86名ASD患者（平均年龄15.3岁）的尾状核和壳核的数量。 MANCOVA显示rs167771 SNP等位基因与纹状体结构体积之间存在关联。此外，较大的尾状核体积与定型行为有关。这些发现支持DRD3基因SNP，纹状体和ASD中的刻板行为之间的关系。

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《The British journal of psychiatry :》 |2015年第5期|共页
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Marieke Langen; Sarah Durston; Sarai van Dijk; Vincent T. Mensen; Wouter G. Staal;
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1. DRD3 gene and striatum in autism spectrum disorder [J] . Staal Wouter G., Langen Marieke, van Dijk Sarai, The British journal of psychiatry : . 2015,第5期

机译：自闭症谱系障碍中的DRD3基因和纹状体
2. Brief report: The dopamine-3-receptor gene (DRD3) is associated with specific repetitive behavior in autism spectrum disorder (ASD) [J] . Staal W.G., De Krom M., De Jonge M.V. Journal of autism and developmental disorders . 2012,第5期

机译：简要报告：多巴胺3受体基因（DRD3）与自闭症谱系障碍（ASD）的特定重复行为相关
3. A common variant in DRD3 receptor is associated with autism spectrum disorder. [J] . de Krom M, Staal WG, Ophoff RA, Biological psychiatry . 2009,第7期

机译：DRD3受体的常见变异与自闭症谱系障碍有关。
4. Classifying Autism Spectrum Disorder (ASD) causal genes based on Intrinsic Disordered Regions [C] . Shula SHAZMAN World Multi-Conference on Systemics, Cybernetics and Informatics . 2020

机译：基于内在无序区域的分类自闭症谱系障碍（ASD）因果基因
5. An Eye-Tracking Measure of Joint Attention as an Autism Spectrum Disorder Endophenotype: Initial Validation in a Community Sample of Adults, Typically Developing Children, and Children with Autism Spectrum Disorder. [D] . Swanson, Meghan R. 2012

机译：作为自闭症谱系障碍内表型的联合注意力的眼动测量：成人，通常为发育中的儿童和患有自闭症谱系障碍的儿童的社区样本中的初步验证。
6. Brief Report: The Dopamine-3-Receptor Gene (DRD3) is Associated with Specific Repetitive Behavior in Autism Spectrum Disorder (ASD) [O] . Wouter G. Staal, Mariken de Krom, Maretha V. de Jonge -1

机译：简要报告：多巴胺3受体基因（DRD3）与自闭症谱系障碍（ASD）的特定重复行为相关。
7. DRD3 gene and striatum in autism spectrum disorder [O] . Wouter G. Staal, Marieke Langen, Sarai van Dijk, 2015

机译：DRD3基因和纹状体在自闭症谱系障碍中

DRD3 gene and striatum in autism spectrum disorder

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