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首页> 外文期刊>The British journal of psychiatry : >Cell adhesion molecule expression in the dorsolateral prefrontal cortex and anterior cingulate cortex in major depression in the elderly
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Cell adhesion molecule expression in the dorsolateral prefrontal cortex and anterior cingulate cortex in major depression in the elderly

机译：老年人严重抑郁症的背外侧前额叶皮层和扣带回皮层中细胞粘附分子的表达

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Background Neuroimaging studies have demonstrated changes in the dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) in major depression. Aims We investigated the expression of cell adhesion molecules (CAMs) in the prefrontal cortex in depression. Method Immunohistochemistry to localise CAMs in post-mortem tissue from 20 subjects with major depression and 20 controls, and image analysis to quantify their expression. Results We found significant increases in CAMs in the grey matter of the DLPFC in the depression group but no comparable differences in the ACC or occipital cortex. In the white matter there was a non-significant increase in intercellular adhesion molecule-I in the DLPFC in the depression group but no increase in the other areas or for vascular cell adhesion molecule-I in any area. Paired tests showed specificity for the DLPFC in the depression group only. Conclusions The increase in CAM expression in the DLPFC suggests an inflammatory reaction and is consistent with ischaemia.
机译：背景神经影像学研究表明，严重抑郁症患者的背外侧前额叶皮层（DLPFC）和前扣带回皮层（ACC）发生了变化。目的我们研究了抑郁症前额叶皮层中细胞粘附分子（CAMs）的表达。方法采用免疫组织化学方法将CAMs定位于20名重度抑郁症患者和20名对照的死后组织中，并进行图像分析以定量其表达。结果我们发现抑郁症组DLPFC灰质中的CAMs显着增加，但ACC或枕叶皮层没有可比的差异。在白质中，抑郁组的DLPFC中细胞间粘附分子-I的增加不显着，但其他区域或血管细胞粘附分子-I的任何区域均没有增加。配对测试显示仅在抑郁症组中对DLPFC有特异性。结论DLPFC中CAM表达的增加提示炎症反应，并与局部缺血一致。

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