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首页> 外文期刊>The British journal of psychiatry : >Effects of antidepressant treatment following myocardial infarction
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Effects of antidepressant treatment following myocardial infarction

机译：心肌梗死后抗抑郁药治疗的效果

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Background Depression following myocardial infarction is associated with poor cardiac prognosis. It is unclear whether antidepressant treatment improves long-term depression status and cardiac prognosis. Aims To evaluate the effects of antidepressant treatment compared with usual care in an effectiveness study. Method In a multicentre randomised controlled trial, 2177 myocardial infarction patients were evaluated for ICDa€“10 depression and randomised to intervention ( n =209) or care as usual ( n =122). Both arms were evaluated at 18 months post-myocardial infarction for long-term depression status and new cardiac events. Results No differences were observed between intervention and control groups in mean scores on the Beck Depression Inventory (11.0, s.d.=7.5 v. 10.2, s.d.=5.1, P =0.45) or presence of ICDa€“10 depression (30.5 v. 32.1%, P =0.68). The cardiac event rate was 14% among the intervention group and 13% among controls (OR=1.07, 95% CI 0.57a€“2.00). Conclusions Antidepressant treatment did not alter long-term depression post-myocardial infarction status or improve cardiac prognosis.
机译：背景心肌梗塞后的抑郁与心脏预后不良有关。目前尚不清楚抗抑郁药是否可以改善长期抑郁状态和心脏预后。目的在有效性研究中评估抗抑郁治疗与常规治疗相比的效果。方法在一项多中心随机对照试验中，对2177例心肌梗死患者的ICDa-10抑郁进行了评估，并随机进行干预（n = 209）或照常护理（n = 122）。在心肌梗塞后18个月对两组患者的长期抑郁状态和新的心脏事件进行了评估。结果贝克抑郁量表的平均得分（11.0，标准差= 7.5 v。10.2，标准差= 5.1，P = 0.45）或ICDa？10抑郁症（30.5 v。32.1％）与干预组和对照组之间没有差异。 ，P ＝ 0.68）。干预组的心脏事件发生率为14％，对照组为13％（OR = 1.07，95％CI 0.57a？2.00）。结论抗抑郁治疗并不能改变心肌梗塞后长期抑郁状态或改善心脏预后。

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