...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The British journal of psychiatry : >Examining interactions between risk factors for psychosis
【24h】

Examining interactions between risk factors for psychosis

机译：检查精神病危险因素之间的相互作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background For complex multifactorial diseases it seems likely that co-exposure to two risk factors will show a greater than additive relationship on disease risk. Aims To test whether greater than additive relationships occur between risk factors for psychosis. Method A cohort study of 50 053 Swedish conscripts. Data on IQ, cannabis use, psychiatric diagnoses, disturbed behaviour and social relations assessed at age 18 were linked to admissions with any non-affective psychoses over a 27-year follow-up period. Statistical interactions between risk factors were examined under both additive and multiplicative models. Results There was some evidence of interaction for eight of the ten combinations of risk factors under additive models, but for only one combination under multiplicative models. Conclusions Multiplicative models describe the joint effect of risk factors more adequately than additive ones do. However, the implications of finding interactions as observed here, or for most interactions reported to date, remain very limited.
机译：背景技术对于复杂的多因素疾病，共同暴露于两种危险因素似乎对疾病风险显示出大于相加的关系。目的测试精神病的危险因素之间是否存在大于加性的关系。方法对50053名瑞典应征入伍者进行队列研究。 18岁时评估的智商，大麻使用，精神病诊断，行为紊乱和社会关系方面的数据与在27年的随访期间接受任何非情感性精神病的入院情况相关。在加性和乘性模型下都检查了风险因素之间的统计相互作用。结果在加性模型下，有十种风险因素组合中的八种存在交互作用的证据，而在乘法模型下，只有一种组合存在相互作用。结论乘法模型比加性模型更能充分描述风险因素的联合效应。但是，发现此处观察到的交互作用或迄今为止报道的大多数交互作用的含义仍然非常有限。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号