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首页> 外文期刊>The British journal of psychiatry : >Comparative effectiveness of second-generation antipsychotics and haloperidol in acute schizophrenia
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Comparative effectiveness of second-generation antipsychotics and haloperidol in acute schizophrenia

机译：第二代抗精神病药和氟哌啶醇在急性精神分裂症中的比较疗效

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Background There is little information on the comparative effectiveness of second-generation antipsychotic agents. Aims To determine if any of five second-generation antipsychotics or haloperidolis more effective in treating acutely ill patients with schizophrenia, schizoaffective disorder or schizophreniform disorder. Method A sample of 327 newly admitted patients were randomised to open-label treatment with aripiprazole, haloperidol, olanzapine, quetiapine, risperidone or ziprasidone for a minimum of 3 weeks. Measures of effectiveness were improvement in mental status so that the patient no longer required acute in-patient care, and changes in Brief Psychiatric Rating Scale (BPRS) scores. Results By the first measure, haloperidol (89%), olanzapine (92%) and risperidone (88%) were significantly more effective than aripiprazole (64%), quetiapine (64%) and ziprasidone (64%). Changes in BPRS ratings were not significant among treatments. Conclusions Haloperidol, olanzapine and risperidone are superior to aripiprazole, quetiapine and ziprasidone for the acute treatment of psychosis in hospitalised patients with schizophrenia, schizoaffective disorder or schizophreniform disorder.
机译：背景信息关于第二代抗精神病药的相对有效性的信息很少。目的确定五种第二代抗精神病药或氟哌啶酮是否对治疗精神分裂症，精神分裂症或精神分裂症样疾病的急性患者更有效。方法将327名新入院的患者随机分为阿立哌唑，氟哌啶醇，奥氮平，喹硫平，利培酮或齐拉西酮进行至少3周的开放标签治疗。有效性的衡量标准是精神状态的改善，以使患者不再需要急性住院治疗，并且简短的精神病学评定量表（BPRS）得分会发生变化。结果乍一看，氟哌啶醇（89％），奥氮平（92％）和利培酮（88％）显着优于阿立哌唑（64％），喹硫平（64％）和齐拉西酮（64％）。 BPRS评分的变化在治疗之间并不显着。结论氟哌啶醇，奥氮平和利培酮在住院精神分裂症，精神分裂症或精神分裂症患者的精神病急性治疗方面优于阿立哌唑，喹硫平和齐拉西酮。

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