• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The British journal of psychiatry : >Comparative effectiveness of second-generation antipsychotics and haloperidol in acute schizophrenia.
【24h】

Comparative effectiveness of second-generation antipsychotics and haloperidol in acute schizophrenia.

机译：第二代抗精神病药和氟哌啶醇在急性精神分裂症中的比较效果。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: There is little information on the comparative effectiveness of second-generation antipsychotic agents. AIMS: To determine if any of five second-generation antipsychotics or haloperidol is more effective in treating acutely ill patients with schizophrenia, schizoaffective disorder or schizophreniform disorder. METHOD: A sample of 327 newly admitted patients were randomised to open-label treatment with aripiprazole, haloperidol, olanzapine, quetiapine, risperidone or ziprasidone for a minimum of 3 weeks. Measures of effectiveness were improvement in mental status so that the patient no longer required acute in-patient care, and changes in Brief Psychiatric Rating Scale (BPRS) scores. RESULTS: By the first measure, haloperidol (89%), olanzapine (92%) and risperidone (88%) were significantly more effective than aripiprazole (64%), quetiapine (64%) and ziprasidone (64%). Changes in BPRS ratings were not significant among treatments. CONCLUSIONS: Haloperidol, olanzapine and risperidone are superior to aripiprazole, quetiapine and ziprasidone for the acute treatment of psychosis in hospitalised patients with schizophrenia, schizoaffective disorder or schizophreniform disorder.
机译：背景：关于第二代抗精神病药比较疗效的信息很少。目的：确定五种第二代抗精神病药或氟哌啶醇中的任何一种是否能更有效地治疗精神分裂症，精神分裂症或精神分裂症患者。方法：将327名新入院的患者随机分为阿立哌唑，氟哌啶醇，奥氮平，喹硫平，利培酮或齐拉西酮进行开放标签治疗至少3周。有效性的衡量标准是精神状态的改善，以使患者不再需要急性住院治疗，并且简短的精神病学评定量表（BPRS）得分会发生变化。结果：从第一方面来看，氟哌啶醇（89％），奥氮平（92％）和利培酮（88％）显着高于阿立哌唑（64％），喹硫平（64％）和齐拉西酮（64％）。 BPRS评分的变化在治疗之间并不显着。结论：氟哌啶醇，奥氮平和利培酮优于阿立哌唑，喹硫平和齐拉西酮在住院治疗的精神分裂症，精神分裂症或精神分裂症患者中可有效治疗精神病。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号