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首页> 外文期刊>The British journal of psychiatry : >Principal components analysis of a large cohort with Tourette syndrome
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Principal components analysis of a large cohort with Tourette syndrome

机译：患有抽动秽语综合征的大型队列的主成分分析

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Background Tourette syndrome is a heterogeneous familial disorder for which the genetic mechanisms are unknown. A better characterisation of the phenotype may help identify susceptibility genes. Aims To extend previous factor-analytic studies of the syndrome. Method Symptom data from 410 people with Tourette syndrome were included in agglomerative hierarchical cluster and principal components analyses. Results Five factors were observed, characterised by: (1) socially inappropriate behaviours and other complex vocal tics; (2) complex motor tics; (3) simple tics; (4) compulsive behaviours; and (5) touching self. Individuals with co-occurring attention-deficit hyperactivity disorder had significantly higher factor scores on Factors 1 and 3, whereas individuals with co-occurring obsessivea€“compulsive disorder and behaviours had significantly higher factor scores for Factors 1a€“4. Conclusions These findings add to the growing body of evidence that Tourette syndrome is not a unitary condition and can be disaggregated into more homogeneous symptom components.
机译：背景技术Tourette综合征是一种异源性家族性疾病，其遗传机制尚不清楚。表型的更好表征可能有助于鉴定易感基因。目的扩展先前对该综合征的因子分析研究。方法将410名图雷特氏综合症患者的症状数据纳入聚结层次聚类和主成分分析。结果观察到五个因素，其特点是：（1）社交不当行为和其他复杂的发音。 （2）复杂的运动神经; （3）简单抽动; （4）强迫行为; （5）触摸自我。并发注意缺陷多动障碍的人在因子1和3上的因子得分明显较高，而并发强迫症和行为同时发生的人在因子1a和4上的因子得分明显更高。结论这些发现增加了越来越多的证据表明Tourette综合征不是单一疾病，可以分解为更均一的症状成分。

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