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首页> 外文期刊>The British journal of psychiatry : >Effect of acute tryptophan depletion on CO2-induced anxiety in patients with panic disorder and normal volunteers
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Effect of acute tryptophan depletion on CO2-induced anxiety in patients with panic disorder and normal volunteers

机译：急性色氨酸耗竭对惊恐症患者和正常志愿者CO2诱发焦虑的影响

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Background Uncertainties remain about the role of serotonin in the aetiology and treatment of panic disorder. Aims To investigate the effect of reducing brain serotonin function on anxiety at rest, and following 5% CO2 provocation in normal controls and patients with panic disorder. Method Twenty drug-free patients with DSM a€” III a€” R panic disorder and 19 controls received a tryptophan-free amino acid drink on one occasion and a control drink on the other in a double-blind, balanced protocol. 5% CO2 was given as a panic challenge after 270 minutes. Results Plasma tryptophan fell by more than 80% both patients and controls after the tryptophan-free drink. Tryptophan depletion did not alter resting anxiety. In patients alone, tryptophan depletion caused a greater anxiogenic response and an increased rate of panic attacks (9 v . 2, P 0.05) after 5% CO2 challenge. No normal volunteers panicked. Conclusions Serotonin may directly modulate panic anxiety in patients with panic disorder. This may underlie the efficacy of serotonergic antidepressants in treating panic disorder.
机译：背景技术关于血清素在恐慌症的病因和治疗中的作用仍不确定。目的探讨正常对照组和恐慌症患者大脑5-羟色胺功能降低对静息焦虑的影响，以及在5％的二氧化碳激发后。方法采用双盲，平衡方案，二十例DSM，III和R型恐慌症的无药患者和19名对照接受了一种不含色氨酸的氨基酸饮料，而另一种接受了对照饮料。 270分钟后，以5％的二氧化碳作为恐慌发作。结果喝无色氨酸后，血浆色氨酸下降了80％以上。色氨酸耗竭并没有改变静息焦虑。单独的患者中，色氨酸耗竭可在5％的CO2刺激后引起更大的焦虑反应和惊慌发作的发生率（9 v。2，P <0.05）。没有正常的志愿者感到惊慌。结论5-羟色胺可直接调节惊恐障碍患者的惊恐焦虑。这可能是血清素能抗抑郁药治疗恐慌症的基础。

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