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首页> 外文期刊>The British journal of psychiatry : >Morphology of the corpus callosum at different stages of schizophrenia: cross-sectional study in first-episode and chronic illness
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Morphology of the corpus callosum at different stages of schizophrenia: cross-sectional study in first-episode and chronic illness

机译：精神分裂症不同阶段的call体形态：首发和慢性疾病的横断面研究

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Background The shape of the corpus callosum may differ in schizophrenia, although no study has compared first-episode with established illness. Aims To investigate the size and shape of the corpus callosum in a large sample of people with first-episode and established schizophrenia. Method Callosal size and shape were determined using high-resolution magnetic resonance imaging on 76 patients with first-episode schizophrenia-spectrum disorders, 86 patients with established schizophrenia and 55 healthy participants. Results There were no significant differences in total area across groups. Reductions in callosal width were seen in the region of the anterior genu in first-episode disorder ( P 0.005). Similar reductions were seen in the chronic schizophrenia group in the anterior genu, but also in the posterior genu and isthmus ( P =0.0005). Conclusions Reductions in anterior callosal regions connecting frontal cortex are present at the onset of schizophrenia, and in established illness are accompanied by changes in other regions of the callosum connecting cingulate, temporal and parietal cortices.
机译：背景精神分裂症中call体的形状可能有所不同，尽管尚无研究将首发病例与确诊疾病进行比较。目的在大量患有首发和已建立的精神分裂症的人群中研究call体的大小和形状。方法使用高分辨率磁共振成像技术对76例首发精神分裂症-频谱障碍患者，86例确诊精神分裂症患者和55名健康受试者进行participants骨大小和形状测定。结果各组总面积无明显差异。在首发疾病中，前骨区域的骨call宽度减小（P <0.005）。在慢性精神分裂症组中，前膝部，后膝部和峡部也有类似的减少（P = 0.0005）。结论在精神分裂症发作时，连接额叶皮层的前call骨区域减少，在已确定的疾病中，连接扣带状，颞叶和顶叶皮层的other骨其他区域发生变化。

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