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首页> 外文期刊>The British journal of psychiatry : >Cigarette smoking as a risk factor for other substance misuse: 10-year study of individuals with and without attention-deficit hyperactivity disorder
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Cigarette smoking as a risk factor for other substance misuse: 10-year study of individuals with and without attention-deficit hyperactivity disorder

机译：抽烟是其他滥用药物的危险因素：患有和没有注意力缺陷多动障碍的个体的十年研究

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Background We previously documented that cigarette smoking is a risk factor for subsequent alcohol and drug misuse and dependence in adolescent girls with attention-deficit hyperactivity disorder (ADHD). Aims To revisit this hypothesis with a large longitudinal sample of both genders followed up for 10 years into young adulthood. Method We used data from two identically designed, longitudinal, casea€“control family studies of boys and girls with and without ADHD ascertained from psychiatric and paediatric sources. We studied 165 individuals with ADHD and 374 controls followed up longitudinally and masked for 10 years. We assessed ADHD, smoking and substance use status using structured diagnostic interviews. We tested the association between cigarette smoking and subsequent substance use outcomes using Cox proportional hazard regression models. Results Youth with ADHD who smoked cigarettes ( n = 27) were significantly more likely to subsequently develop drug misuse and dependence compared with youth with ADHD who did not smoke ( n = 138, P 0.05). Conclusions These results confirm that cigarette smoking increases the risk for subsequent drug and alcohol use disorders among individuals with ADHD. These findings have important public health implications, and underscore the already pressing need to prevent smoking in children with ADHD.
机译：背景：我们以前的文献表明，吸烟是引起注意力缺陷多动障碍（ADHD）的青春期女孩随后酗酒和滥用药物以及依赖的危险因素。目的为了对这一假设进行重新研究，采用大量的男女纵向样本，对成年后的青少年进行了长达10年的随访。方法我们使用了来自精神病学和儿科病源的两个设计相同的纵向病例对照家庭研究的男孩和女孩患有或不患有ADHD的数据。我们研究了165名患有ADHD的患者和374名对照的患者，进行了纵向随访，并进行了10年的掩蔽。我们通过结构化的诊断访谈评估了多动症，吸烟和药物使用状况。我们使用Cox比例风险回归模型测试了吸烟与后续药物使用结果之间的关联。结果与不吸烟的多动症青少年相比，吸烟的多动症青少年（n = 27）与不吸烟的多动症青少年（n = 138，P <0.05）相比，发生滥用和依赖性的可能性更高。结论这些结果证实，吸烟增加了多动症患者继发的药物和酒精使用障碍的风险。这些发现具有重要的公共卫生意义，并强调了预防多动症儿童吸烟的迫切需求。

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