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首页> 外文期刊>The British journal of psychiatry : >Implications for psychedelic-assisted psychotherapy: functional magnetic resonance imaging study with psilocybin
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Implications for psychedelic-assisted psychotherapy: functional magnetic resonance imaging study with psilocybin

机译：对迷幻心理疗法的影响：psilocybin的功能磁共振成像研究

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Background Psilocybin is a classic psychedelic drug that has a history of use in psychotherapy. One of the rationales for its use was that it aids emotional insight by lowering psychological defences. Aims To test the hypothesis that psilocybin facilitates access to personal memories and emotions by comparing subjective and neural responses to positive autobiographical memories under psilocybin and placebo. Method Ten healthy participants received two functional magnetic resonance imaging scans (2 mg intravenous psilocybin v. intravenous saline), separated by approximately 7 days, during which they viewed two different sets of 15 positive autobiographical memory cues. Participants viewed each cue for 6 s and then closed their eyes for 16 s and imagined re-experiencing the event. Activations during this recollection period were compared with an equivalent period of eyes-closed rest. We split the recollection period into an early phase (first 8 s) and a late phase (last 8 s) for analysis. Results Robust activations to the memories were seen in limbic and striatal regions in the early phase and the medial prefrontal cortex in the late phase in both conditions ( P 0.001, whole brain cluster correction), but there were additional visual and other sensory cortical activations in the late phase under psilocybin that were absent under placebo. Ratings of memory vividness and visual imagery were significantly higher after psilocybin ( P 0.05) and there was a significant positive correlation between vividness and subjective well-being at follow-up ( P 0.01). Conclusions Evidence that psilocybin enhances autobiographical recollection implies that it may be useful in psychotherapy either as a tool to facilitate the recall of salient memories or to reverse negative cognitive biases.
机译：背景赛洛西宾是一种经典的迷幻药，在心理治疗中已有使用史。使用它的理由之一是它通过降低心理防御能力来帮助情绪洞察。目的通过比较在psilocybin和安慰剂作用下对阳性自传体记忆的主观和神经反应，来测试psilocybin有助于获得个人记忆和情绪的假设。方法十名健康参与者接受了两次功能性磁共振成像扫描（2 mg静脉内psilocybin诉静脉内生理盐水），间隔约7天，在此期间，他们观察了两组不同的15种阳性自传体记忆线索。参加者查看每个提示6秒钟，然后闭上眼睛16秒钟，并想象重新体验该事件。将这段回忆期间的激活时间与等效的闭眼休息时间进行了比较。我们将收集时间分为早期（前8 s）和后期（后8 s）进行分析。结果在两种情况下，早期的边缘和纹状体区域以及晚期的内侧前额叶皮层均对记忆有强大的激活作用（P <0.001，全脑簇校正），但是视觉和其他感觉皮层激活在psilocybin的晚期处于安慰剂下。 psilocybin治疗后，记忆生动度和视觉图像的评分显着较高（P <0.05），随访时生动度与主观幸福感之间呈显着正相关（P <0.01）。结论psilocybin增强自传体回忆的证据表明，它可以在心理治疗中用作促进显着记忆的回忆或逆转负面认知偏见的工具。

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