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首页> 外文期刊>The British journal of psychiatry : >Vitamin D deficiency in patients with intellectual disabilities: prevalence, risk factors and management strategies
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Vitamin D deficiency in patients with intellectual disabilities: prevalence, risk factors and management strategies

机译：智力障碍患者的维生素D缺乏症：患病率，危险因素和管理策略

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Background People with intellectual disabilities have a high risk of osteoporosis and fractures, which could partly be as a result of vitamin D deficiency. Aims To compare the serum vitamin D (25(OH)D) levels of 155 patients with intellectual disabilities under psychiatric care and 192 controls, investigate potential risk factors for vitamin D deficiency in people with intellectual disabilities and assess available treatments. Method Cross-sectional observational study followed by treatment evaluation. Results Almost twice as many patients with intellectual disabilities had vitamin D deficiency (25(OH)D 50 nmol/l) compared with controls (77.3% v. 39.6%, P 0.0001). In the intellectual disabilities group, winter season ( P 0.0001), dark skin pigmentation ( P 0.0001), impaired mobility ( P = 0.002) and obesity ( P = 0.001) were independently associated with lower serum 25(OH)D. In most patients, 800 IU colecalciferol daily normalised 25(OH)D levels. Conclusions Vitamin D deficiency is highly prevalent in people with intellectual disabilities, partly because of insufficient exposure to sunlight. Screening and treatment strategies, aiming to reduce these patientsa€? high fracture risk, should be introduced. Similar strategies may be required in other psychiatric populations at risk for fractures and with a tendency to spend excessive time indoors.
机译：背景技术智障人士患骨质疏松症和骨折的风险很高，其部分原因可能是维生素D缺乏。目的比较155例精神病患者和192名对照组智障患者的血清维生素D（25（OH）D）水平，调查智障人士维生素D缺乏症的潜在危险因素，并评估可用的治疗方法。方法横断面观察研究，然后进行治疗评估。结果与对照组（77.3％vs. 39.6％，P <0.0001）相比，智力障碍患者的维生素D缺乏症（25（OH）D <50 nmol / l）几乎多两倍。在智力障碍人群中，冬季（P <0.0001），皮肤色素沉着（P <0.0001），行动不便（P = 0.002）和肥胖（P = 0.001）与较低的血清25（OH）D相关。在大多数患者中，每天800 IU降钙素醇使25（OH）D水平正常化。结论维生素D缺乏症在智障人士中非常普遍，部分原因是阳光照射不足。旨在减少这些患者的筛查和治疗策略高骨折风险，应引入。在其他有骨折危险并倾向于在室内花费大量时间的精神病患者中，可能需要采取类似的策略。

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