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首页> 外文期刊>The EPMA journal. >New animal models of progressive neurodegeneration: tools for identifying targets in predictive diagnostics and presymptomatic treatment
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New animal models of progressive neurodegeneration: tools for identifying targets in predictive diagnostics and presymptomatic treatment

机译：进行性神经退行性疾病的新动物模型：用于预测性诊断和对症治疗的靶标识别工具

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摘要

Mental and neurological disorders are increasingly prevalent and constitute a major societal and economic burden worldwide. Many of these diseases and disorders are characterized by progressive deterioration over time, that ultimately results in identifiable symptoms that in turn dictate therapy. Disease-specific symptoms, however, often occur late in the degenerative process. A better understanding of presymptomatic events could allow for the development of new diagnostics and earlier interventions that could slow or stop the disease process. Such studies of progressive neurodegeneration require the use of animal models that are characterized by delayed or slowly developing disease phenotype(s). This brief review describes several examples of such animal models that have recently been developed with relevance to various neurological diseases and disorders, and delineates the potential of such models to aid in predictive diagnosis, early intervention and disease prevention.
机译：精神和神经疾病越来越普遍，并构成了世界范围内的主要社会和经济负担。这些疾病中的许多特征都是随着时间的推移逐渐恶化，最终导致可识别的症状，进而决定了治疗方法。但是，特定于疾病的症状通常发生在退化过程的后期。对症状前事件的更好理解可以允许开发新的诊断方法和更早的干预措施，以减缓或终止疾病进程。这种进行性神经退行性疾病的研究需要使用以疾病表型延迟或缓慢发展为特征的动物模型。这篇简短的综述描述了最近与各种神经系统疾病和失调相关的动物模型的几个例子，并描述了这种模型有助于预测性诊断，早期干预和疾病预防的潜力。

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