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首页> 外文期刊>The EPMA journal. >Predictive molecular profiling in blood of healthy vasospastic individuals: clue to targeted prevention as personalised medicine to effective costs
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Predictive molecular profiling in blood of healthy vasospastic individuals: clue to targeted prevention as personalised medicine to effective costs

机译：健康的血管痉挛个体的血液中的预测性分子谱分析：作为有效成本的个性化药物的靶向预防的线索

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摘要

Paradigm change from late interventional approach to predictive diagnostics followed by targeted prevention before manifest pathology, presents innovative concept for advanced healthcare. Preselection of healthy but pathology-predisposed individuals is the primary task in the overall action. Vasospasm is a frequent syndrome defined as an inappropriate constriction or insufficient dilatation in microcirculation. Vasospastic individuals are considered as healthy subpopulation predisposed to several pathologies including neurodegeneration. Clinical observations, subcellular imaging and “gene hunting”-investigations provide evidence for vasospasm as predisposition to glaucoma; development of further related pathologies cannot be excluded. Predictive molecular-profiling in blood can specify individual predisposition for effective prevention.
机译：从晚期介入治疗到预测性诊断再到明显病理之前的有针对性的预防，范式的转变为高级医疗保健提出了创新的概念。健康但病理易感的个体的预选是整体行动的主要任务。血管痉挛是一种常见的综合征，定义为微循环不适当的收缩或扩张不足。血管痉挛个体被认为是易患多种疾病（包括神经退行性病变）的健康亚人群。临床观察，亚细胞成像和“基因狩猎”研究提供了血管痉挛作为青光眼易感性的证据。不能排除其他相关病理的发展。血液中的预测性分子图谱可以指定个体易感性，以进行有效的预防。

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