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首页> 外文期刊>The Internet Journal of Pharmacology >Hypoglycemic Action of Seed Kernel of Caesalpinia bonducella Fleming In Normal and Alloxan- Induced Diabetic Albino Rats
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Hypoglycemic Action of Seed Kernel of Caesalpinia bonducella Fleming In Normal and Alloxan- Induced Diabetic Albino Rats

机译：正常和四氧嘧啶诱导的糖尿病白化病大鼠马鞭草种子核的降血糖作用

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The aim of the present study is to evaluate the hypoglycemic action of ethanolic extract of seed kernel of Caesalpinia bonducella Fleming on normal and alloxan-induced diabetic albino rats. The ethanolic extract (200mg/kg/d) was administered orally for two weeks to alloxan-induced diabetic rats. Blood glucose was estimated every week for two consecutive weeks along with body weight monitoring. For evaluation of mechanism of action of test drug, glycogen estimation was done in liver, heart and skeletal muscle and effect on adrenaline-induced hyperglycemia was seen. The test drug significantly (p<0.05) reduced the rise in blood glucose induced by alloxan. The test drug produced significant (p<0.05) increase in liver glycogen and also significantly (p<0.05) reduced adrenaline-induced hyperglycaemia. Significant (p<0.05) lowering of normal blood glucose was also found. Thus, the seed kernel of Caesalpinia bonducella has significant antidiabetic and hypoglycemic activity. Sources and Support Animals: Central Animal House, A.M.C.H., Dibrugarh, Assam. Drugs & Equipment: Department of Pharmacology, A.M.C.H, Dibrugarh. Introduction Diabetes mellitus is a major endocrine disorder affecting nearly 10% of population all over the world 1 . According to the world ethnobotanical information reports, almost 800 plants may possess antidiabetic potential. In the past decade, research has been focused on scientific evaluation of traditional drugs of plant origin and screening of more effective and safe hypoglycemic agents has continued to be an important area 2 . Caesalpinia bonducella (L.) Fleming (Syn. Caesalpinia bonduc (L.) Roxb. ; Syn. Caesalpinia crista Linn.), belonging to the family Fabaceae, is a shrub widely distributed all over the world especially, in India, Sri Lanka and Andaman and Nicobar Islands 3 . All parts of the plant have medicinal properties 4 . The plant has been reported to possess anxiolytic 5 , antinociceptive, antidiarrhoeal 6 and antifilarial activities 7 . Phytochemical analysis of seeds of Caesalpinia bonducella has revealed the presence of alkaloids, flavonoids, glycosides, saponins, tannins and triterpenoids 78 . The powdered seed kernel of Caesalpinia bonducella is used by the local people of Assam in the treatment of diabetes. Keeping this in view, the present study was aimed at evaluating the hypoglycemic activity of ethanolic extract of the seed kernel of Caesalpinia bonducella on normal and alloxan-induced diabetic albino rats with stress on evaluation of probable mechanism of antidiabetic action. Materials And Methods Plant material and extraction The seeds of Caesalpinia bonducella Fleming were collected from the local market in Dibrugarh in the months of June to August. The plant material was authenticated by Dr. L.R. Saikia, Reader, Department of Life Sciences, Dibrugarh University, Dibrugarh. A voucher specimen (No. DU/LS/212) was deposited at the Department of Life Sciences, Dibrugarh University. The seed kernels of Caesalpinia bonducella Fleming were manually separated from the outer seed shell, air dried, powdered (1200 g) and ethanolic extracts were prepared using 90% ethanol by percolation method 9 followed by steam evaporation. A final yield of 133.5 g of the extract (11.1% w/w) was obtained. Animals Healthy adult Wistar albino rats (Rattus norvegicus) weighing 200—250 grams each were used for the study. All the animals were taken care of under ethical consideration as per the guidelines of the CPCSEA with due approval from the Institutional Animal Ethical Committee (Registration no: 634/02/a/CPCSEA; dated 19/5/2002).Acute toxicity study Acute oral toxicity test for the ethanolic extract of seed kernel of Caesalpinia bonducella Fleming (EESKCB) was carried out as per OECD Guidelines 425 10 . When administered orally, seed extract of Caesalpinia bonducella was found to be relatively non-toxic 5 . As such, the limit test at 2000 mg/kg was performed. One–tenth of the upper bound dose of the extract fr
机译：本研究的目的是评估乙醇结合种子Caesalpinia bonducella Fleming籽仁乙醇提取物对正常和四氧嘧啶糖尿病白化病大鼠的降血糖作用。将乙醇提取物（200mg / kg / d）口服给予四氧嘧啶诱发的糖尿病大鼠两周。每周连续两个星期估计血糖，并进行体重监测。为了评估受试药物的作用机理，在肝，心脏和骨骼肌中进行了糖原估计，并观察到了对肾上腺素诱导的高血糖的影响。受试药物显着（p <0.05）减少了四氧嘧啶引起的血糖升高。受试药物的肝糖原水平显着增加（p <0.05），并且肾上腺素诱导的高血糖显着降低（p <0.05）。还发现正常血糖显着降低（p <0.05）。因此，Caesalpinia bonducella的种子仁具有显着的抗糖尿病和降血糖活性。来源和支持动物：阿萨姆邦迪布鲁加的A.M.C.H. Central Animal House。药品和设备：迪布鲁加（A.M.C.H）药理学系。引言糖尿病是一种主要的内分泌疾病，影响了全世界近10％的人口1。根据世界民族植物学信息报道，将近800种植物具有抗糖尿病的潜力。在过去的十年中，研究一直集中在对植物传统药物的科学评估上，筛选更有效，更安全的降血糖药一直是重要的领域2。 es草（Caesalpinia bonducella（L.）Fleming（Syn。Caesalpinia bonduc（L.）Roxb。; Syn。Caesalpinia crista Linn。）），隶属于Fabaceae，是一种灌木，分布于世界各地，特别是在印度，斯里兰卡和安达曼和尼科巴群岛3。植物的所有部分均具有药用特性4。据报道该植物具有抗焦虑药5，抗伤害感受，抗腹泻6和抗丝虫活性7。凯撒莲种子的植物化学分析表明，存在生物碱，类黄酮，糖苷，皂苷，单宁和三萜类化合物78。阿萨姆邦人将撒撒粉状种子核仁粉末状粉末用于治疗糖尿病。鉴于此，本研究旨在评估Caesalpinia bonducella种子仁乙醇提取物对正常和四氧嘧啶诱导的糖尿病白化病大鼠的降血糖活性，以评估其可能的抗糖尿病作用。材料和方法植物材料和提取6月至8月的几个月中，从Dibrugarh的当地市场采集了Caesalpinia bonducella Fleming的种子。植物材料由L.R. Dr. Saikia，迪布鲁加尔大学生命科学系读者。凭证样本（编号DU / LS / 212）存放在Dibrugarh大学生命科学系。从种子外皮中手动分离出Caesalpinia bonducella Fleming的种子粒，风干，粉化（1200克），并使用90％乙醇通过渗滤法9制备乙醇提取物，然后进行蒸汽蒸发。最终产量为133.5 g提取物（11.1％w / w）。动物使用每只重200-250克的健康成年Wistar白化病大鼠（Rattus norvegicus）进行研究。急性中毒研究急性中毒研究急性中毒研究急性中毒研究急性中毒研究急性中毒研究急性毒性研究急性根据OECD指南425 10进行了Caesalpinia bonducella Fleming（EESKCB）种子仁乙醇提取物的口服毒性试验。当口服给药时，发现凯撒叶莲的种子提取物相对无毒5。这样，进行了2000mg / kg的极限试验。提取物上限剂量的十分之一

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