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首页> 外文期刊>The Internet Journal of Pharmacology >Drug Induced Hepatotoxicity: A Comprehensive Review
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Drug Induced Hepatotoxicity: A Comprehensive Review

机译：药物诱导的肝毒性：综述

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Liver, the largest organ in the body is being evolved to maintain the body’s internal milieu and also protect itself from the challenges it faces during its functioning. It is a vital organ having diverse functions. It plays an important role not only in the metabolism, synthesis and storage but also in the detoxification of many endogenous and exogenous compounds and converting them to less toxic substances for excretion. Hepatotoxicity implies chemical-driven liver damage. Certain medicinal agents when taken in overdoses and sometimes even when introduced within therapeutic ranges may injure the liver. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents. The present review provides an overview of various drugs causing hepatotoxicity, various types of drug induced hepatotoxicity and their mechanisms.
机译：肝脏是人体最大的器官，正在进化以维持人体的内部环境，并保护自己免受其在运作过程中面临的挑战。它是具有多种功能的重要器官。它不仅在代谢，合成和储存中起着重要作用，而且在许多内源性和外源性化合物的解毒以及将其转化为毒性较小的物质进行排泄方面也起着重要的作用。肝毒性意味着化学驱动的肝损伤。某些药物过量服用时，有时甚至在治疗范围内引入时，可能会损害肝脏。肝脏在转化和清除化学物质中起着核心作用，并且容易受到这些药物的毒性作用。本综述概述了引起肝毒性的各种药物，各种类型的药物诱导的肝毒性及其作用机理。

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