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首页> 外文期刊>The Internet Journal of Pharmacology >Effect Of Co-Administration Of Venlafaxine And Perindopril To Uninephrectomized DOCA-Salt-Treated Albino Rats.
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Effect Of Co-Administration Of Venlafaxine And Perindopril To Uninephrectomized DOCA-Salt-Treated Albino Rats.

机译：Venlafaxine和Perindopril共同给药对未切下线的DOCA-盐处理的白化大鼠的影响。

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The present study investigates the effect of combination of the antidepressant venlafaxine (serotoninoradrenaline reuptake inhibitor, SNRI) with the angiotensin converting enzyme inhibitor perindopril on the immobility time in the forced swimming test (FST) as well as on systolic blood pressure (SBP) in uninephroctemized DOCA salt-treated rats as a model of experimental hypertension. The FST is a behavioral test used to predict the efficacy of antidepressant treatments. It has a good predictive value for antidepressant potency in humans . This is to try to provide an experimental study about the benefit of the use of perindopril as a better antihypertensive in hypertensive patients with co-morbidity like depression or anxiety.Albino rats were divided into 4 groups; Group 1 (control) uninephrectomized without DOCA injection; Group 2 was uninephrectomized and received DOCA without any treatment. Group 3 were uninephrectomized and received DOCA then venlafaxine only in a dose of 8 mg/kg i. p. 30 min. before FST; Group 4 was uninephrectomized and received DOCA then the interacting drugs before FST. SBP measurements were conducted in all groups over a period of 8 hours post-injection at 30 min. intervals. Results revealed that perindopril potentiates the anti-immobility effect of venlafaxine. Additionally, venlafaxine did not affect the anti-hypertensive effect of perindopril. Venlafaxine did not change the SBP of non-hypertensive albino rats as showed in a pilot study.These results could provide a support for the effective use of venlafaxine in association with perindopril in hypertension and depression co-morbidity.
机译：本研究调查了抗抑郁药文拉法辛（5-羟色胺/去甲肾上腺素再摄取抑制剂，SNRI）与血管紧张素转化酶抑制剂培哚普利的结合时间对强制游泳试验（FST）的不动时间以及收缩压（SBP）的影响。在未经加氢的DOCA盐治疗的大鼠中作为实验性高血压的模型。 FST是一种行为测试，用于预测抗抑郁药治疗的疗效。它对人类的抗抑郁药具有很好的预测价值。这是为了提供实验研究，以培哚普利作为更好的降压药在合并抑郁症或焦虑症等合并症患者中的益处。白化病大鼠分为4组;每组4只。未注射DOCA的第1组（对照组）未切除;第2组未行全直肠切除术，未经任何治疗即接受DOCA治疗。第3组未进行全直肠切除术，仅接受8 mg / kg i剂量的DOCA，然后接受文拉法辛。 p。 30分钟。 FST之前;第4组未进行全直肠切除术，在FST前接受DOCA，然后接受相互作用药物。在注射后30分钟的8小时内对所有组进行SBP测量。间隔。结果显示培哚普利增强了文拉法辛的抗固定作用。此外，文拉法辛不影响培哚普利的抗高血压作用。如一项先导研究显示，文拉法辛未改变非高血压白化病大鼠的SBP，这些结果可为将文拉法辛与培哚普利联用于高血压和抑郁合并症的有效支持提供支持。

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