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首页> 外文期刊>The Internet Journal of Pharmacology >Therapeutic Effect Of Nigella Sativa Oil On Different Clinical And Biochemical Parameters In Metabolic Syndrome
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Therapeutic Effect Of Nigella Sativa Oil On Different Clinical And Biochemical Parameters In Metabolic Syndrome

机译：苜蓿油对代谢综合征不同临床和生化指标的治疗作用

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Introduction: The seeds of Nigella sativa plant have been used to promote health and fight disease for centuries especially in the Middle East and Southeast Asia. This plant has been a great focus of research. This clinical study was undertaken to know the adjuvant effect of Nigella sativa oil on various clinical and biochemical parameters of Insulin resistance syndrome. Methodology: This prospective randomized control study was conducted at the tertiary health care centre of north India. After final diagnosis and considering inclusion and exclusion criteria one hundred and sixty one patients were enrolled in this study. Informed and written consent was taken from all the patients enrolled. Approval from institutional ethical committee was taken. Patients were divided into two groups. In-group I (standard group) patients were advised atorvastatin 10 mg once a day, metformin 500 mg twice a day, atenolol 50 mg once a day, amlodipine 5 mg once a day for a period of six weeks. In group II (Nigella sativa) group, patients were advised the above standard medication plus Nigella sativa oil 2.5 twice daily for a period of six weeks. Blood sugar both fasting and postprandial, fasting lipid profile and different parameters of obesity were recorded before therapy and after completion of therapy. Result: The abovementioned methodology was followed and it was found that the difference of percentage improvement in group II was significant with reference to low density lipoprotein, high density lipoprotein and fasting blood glucose (p<.05). Conclusion: Nigella sativa oil was found to be effective as add on therapy in patients of insulin resistance syndrome. Nigella sativa oil has a significant activity in diabetic and dyslipidemic patients. Introduction The National Cholesterol Education Program's Adult Treatment Panel III report (ATP III) identified the metabolic syndrome as a multiplex risk factor for cardiovascular disease (CVD) that is deserving of more clinical attention. The etiology, prevention and treatment of the metabolic syndrome are currently the focus of intense research activities. As public health epidemics go, metabolic syndrome does not seem to pack the punch of more sharply defined health threats, such as lung cancer or heart disease. But statistics expose some harsh realities. According to a 2002 report from the centre for disease control and prevention, about 22% of United States adults have metabolic syndrome. Expert believe that the report, based on data collected between 1988 and 1994 underestimate the current number of persons who have metabolic syndrome.Alternative medicine has opened new door for the treatment of cardiometabolic disorders which has attained epidemic proportion throughout the world. Nigella sativa seed, used for centuries for medicinal and culinary purposes and reported to possess a number of pharmacological properties, including antioxidant, anti-inflammatory, hypoglycemic, antihypertensive and antihyperlipidemic properties 1 . But no study had been done previously in patients of metabolic syndrome. Hence it was considered worthwhile to study the adjuvant effect of Nigella sativa oil on various clinical and biochemical parameters in patients of Metabolic Syndrome.The seeds of Nigella sativa plant have been used to promote health and fight disease for centuries especially in the Middle East and Southeast Asia. In South Asia, it is called Kalonji, its Arabic name is Habat-ul-Sauda and its English name is Black cumin. .The plant is widely grown in different parts of the world and is an annual herb cultivated in India. As an oriental spice, Nigella sativa has long been used as a natural remedy for the treatment of many acute as well as chronic diseases. This plant has been a great focus of research and has several traditional uses and consequently has been extensively studied for its chemical constituents and biological activities.
机译：简介：几个世纪以来，尤其是在中东和东南亚，已将黑夜蛾植物的种子用于促进健康和抵抗疾病。该植物一直是研究的重点。进行这项临床研究是为了了解黑木薯油对胰岛素抵抗综合征的各种临床和生化指标的佐剂作用。方法：这项前瞻性随机对照研究在印度北部的三级医疗中心进行。经过最终诊断并考虑入选和排除标准后，本研究纳入了161名患者。所有登记患者均已获得知情和书面同意。已获得机构道德委员会的批准。患者分为两组。在I组（标准组）患者中，建议阿托伐他汀每天一次10毫克，二甲双胍每天500毫克，阿替洛尔每天一次50毫克，氨氯地平每天一次5毫克，共六周。在第二组（Nigella sativa）组中，建议患者每天两次以上标准药物加Nigella sativa oil 2.5，持续六周。在治疗前和治疗结束后记录空腹和餐后血糖，空腹血脂谱和肥胖的不同参数。结果：采用上述方法，结果发现，与低密度脂蛋白，高密度脂蛋白和空腹血糖相比，第二组的改善百分比差异显着（p <.05）。结论：发现Nigella sativa oil可作为胰岛素抵抗综合征患者的补充疗法。 Nigella sativa oil在糖尿病和血脂异常患者中具有重要活性。简介国家胆固醇教育计划的成人治疗小组III报告（ATP III）将代谢综合征确定为心血管疾病（CVD）的多重危险因素，值得更多的临床关注。代谢综合征的病因学，预防和治疗是当前激烈研究活动的重点。随着公共卫生流行病的发展，新陈代谢综合症似乎并没有对更明确定义的健康威胁（如肺癌或心脏病）产生冲击。但是统计数据暴露了一些严酷的现实。根据疾病控制和预防中心2002年的报告，约22％的美国成年人患有代谢综合征。专家认为，该报告基于1988年至1994年收集的数据，低估了目前患有代谢综合征的人数。替代医学为治疗心脏代谢疾病打开了新的大门，该疾病已在世界范围内流行。紫花苜蓿种子，几个世纪以来一直用于医药和烹饪目的，据报道具有许多药理特性，包括抗氧化，抗炎，降糖，降压和降血脂特性1。但是以前没有对代谢综合征患者进行研究。因此，研究紫花苜蓿油对代谢综合症患者各种临床和生化指标的佐剂作用被认为是值得的。紫花苜蓿植物的种子被用于促进健康和抗击疾病已有多个世纪，特别是在中东和东南部亚洲。在南亚，它被称为Kalonji，阿拉伯名称是Habat-ul-Sauda，英语名称是Black cumin。 。该植物在世界各地广泛种植，是印度一年生的草本植物。作为一种东方香料，Nigella sativa长期以来一直被用作治疗许多急性和慢性疾病的天然药物。该植物一直是研究的重点，具有多种传统用途，因此对其化学成分和生物活性进行了广泛的研究。

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