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首页> 外文期刊>The Internet Journal of Pharmacology >Anti-ulcer effect of Cordia dichotoma Forst .f. fruits against gastric ulcers in rats.
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Anti-ulcer effect of Cordia dichotoma Forst .f. fruits against gastric ulcers in rats.

机译：二化Cor的抗溃疡作用水果对大鼠胃溃疡。

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The anti-ulcer effect of extracts of Cordia dichotoma Forst.f. fruits (300mg/kg body weight) was studied in albino rats of Wistar strain using three different models i.e. pyloric ligation, aspirin and indomethacin induced ulcers. The extractions of C.dichotoma Forst.f. fruits were carried out using ethanol. This extract was fractionated using petroleum ether, solvent ether, ethyl acetate, butanol and butanone in succession. Gastric mucosal injury was produced in rats by pyloric ligation, aspirin and indomethacin induced models. Extracts of petroleum ether, solvent ether, ethyl acetate, butanol and butanone were administered in a dose of 300 mg/kg body weight. The parameters taken to assess anti-ulcer activity were volume of gastric secretion, free acidity, total acidity and ulcer index. The results indicates that, extracts of ethyl acetate, butanol and butanone significantly (p< 0.001) decrease the volume of gastric secretion, free acidity, total acidity and ulcer index with respect to control. The results suggest that the extracts of Cordia dichotoma Forst.f. fruits possess significant anti-ulcer activity. Introduction >C. dichotoma Forst.f. a plant belonging to family Boraginaceae is medium sized tree with a short, usually crooked trunk 3-4 ft. in girth 1 . The fruits are globose, yellowish-brown, pink or black and pulpy. The plant grows in India, Sri Lanka and other warmer regions. The medicinal attributes of C.dichotoma have been known since a long time. The fruits of the plant are used as cooling, astringent, emollient, expectorant, anthelmintic, purgative and diuretic 2 . A number of pharmacological properties such as analgesic, antiinflammatory and hepatoprotective have been reported 345 . The study assumes significance in the context that prolonged use of synthetic anti-ulcer drugs leads to adverse drug reactions and search for new anti-ulcer agents that retain therapeutic efficacy and are devoid of adverse drug reaction is warranted. A study of the efficacy of an extracts of C. dichotoma fruits in gastric ulcer with pyloric ligation, aspirin and indomethacin induced ulcers was under taken in rat models. Materials And Methods Preparation of plant extracts The fruits of C.dichotoma were purchased from local market of Hubli and were authenticated by Prof V. S Huddar, Department of Botany, H. S. K Science and S. K Arts College, Hubli. The collected fruits were shade dried, reduced to coarse powder (2 kg) and subjected to repeated exhaustive extraction in batches with ethanol in a soxhlet extractor. After complete extraction the alcoholic extract (68 gm) was then suspended in water and further fractionated using petroleum ether (8 gm), solvent ether (2 gm), ethyl acetate (4 gm) butanol (5.5 gm) and butanon (2.5) in succession. These extracts were vacuum dried and used for anti-ulcer activity. Tween 80 (1%) was used as vehicle to suspend the extracts. Phytochemical screening All the extracts were subjected to phytochemical analysis as per standard procedures 6 to know the nature of phytoconstituents present (TABLE 1). The major active constituents were found in extracts includes flavanoids, alkaloids and saponins. Among all active constituents flavanoids were found to be in higher concentrations.
机译：香茅提取物的抗溃疡作用使用三种不同的模型，即幽门结扎，阿司匹林和吲哚美辛诱发的溃疡，在Wistar菌株的白化病大鼠中研究了水果（300mg / kg体重）。 C.dichotoma Forst.f。的提取水果用乙醇进行。依次使用石油醚，溶剂醚，乙酸乙酯，丁醇和丁酮将该萃取物分级分离。幽门结扎，阿司匹林和消炎痛诱导的模型在大鼠中产生胃粘膜损伤。以300mg / kg体重的剂量施用石油醚，溶剂醚，乙酸乙酯，丁醇和丁酮的提取物。评估抗溃疡活性的参数是胃分泌物的体积，游离酸度，总酸度和溃疡指数。结果表明，与对照相比，乙酸乙酯，丁醇和丁酮的提取物显着降低胃分泌物的体积，游离酸度，总酸度和溃疡指数（p <0.001）。结果表明，Cordia dichotoma Forst.f。的提取物。水果具有明显的抗溃疡活性。简介> C。双歧杆菌属于紫草科的一种植物是中型树，其周长为3-4英尺，短而弯曲的树干。果实为球形，黄褐色，粉红色或黑色，肉质。该植物生长在印度，斯里兰卡和其他较温暖的地区。梭状芽胞杆菌的药用属性由来已久。该植物的果实用作凉爽剂，收敛剂，润肤剂，祛痰剂，驱虫药，泻药剂和利尿剂2。 345有许多药理特性，如止痛药，抗炎药和保肝药。在长期使用合成抗溃疡药物会导致药物不良反应的背景下，这项研究具有重要意义。因此，有必要寻找能够保留治疗功效且没有药物不良反应的新型抗溃疡药物。在大鼠模型中，对幽门螺杆菌果实提取物在幽门结扎，阿司匹林和消炎痛诱导的溃疡中治疗胃溃疡的功效进行了研究。材料和方法植物提取物的制备dic草的果实购自Hubli的当地市场，并由Hubik的植物学系V.S Huddar教授和Hubli的S.K艺术学院鉴定。将收集到的水果进行阴凉干燥，减至粗粉（2 kg），然后在索氏提取器中用乙醇分批反复反复彻底萃取。完全提取后，将乙醇提取物（68 gm）悬浮在水中，并进一步用石油醚（8 gm），溶剂醚（2 gm），乙酸乙酯（4 gm）丁醇（5.5 gm）和丁酮（2.5）进行分馏。演替。将这些提取物真空干燥并用于抗溃疡活性。吐温80（1％）被用作悬浮提取物的载体。植物化学筛选按照标准程序6对所有提取物进行植物化学分析，以了解存在的植物成分的性质（表1）。提取物中发现的主要活性成分包括类黄酮，生物碱和皂苷。在所有活性成分中，黄酮类化合物含量较高。

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