Wegener’s Granulomatosis presenting with multiple cranial neuropathies.

Max R. Lowden; Aiesha Ahmed

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Wegener’s Granulomatosis presenting with multiple cranial neuropathies.

机译：韦格纳肉芽肿病伴多发颅神经病变。

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A 41–year-old man had headaches, hearing loss, and left facial palsy for five months. Examination was remarkable for left seventh nerve palsy, left sided hearing loss and hemi tongue atrophy. MRI showed left cerebellopontine angle dural thickening.(Figure1and 2). Laboratory studies (CSF and blood) were unremarkable for an infectious, neoplastic and autoimmune etiology except for an elevated Anti-neutrophil cytoplasmic antibody titer. A dural biopsy showed chronic inflammation with granuloma formation. He was started on prednisone with plans to start immunosuppresants as outpatient. Wegener’s Granulomatosis can present with multiple cranial neuropathies as initial clinical manifestation1 due to focal meningeal involvement 2.

机译：一名41岁的男人有头痛，听力下降和面部麻痹五个月。检查对于左第七神经麻痹，左侧听力下降和半舌萎缩非常显着。 MRI显示左小脑桥脑硬膜增厚（图1和2）。除抗中性粒细胞胞浆抗体滴度升高外，实验室研究（CSF和血液）对感染性，赘生性和自身免疫性病因的影响不明显。硬脑膜活检显示出慢性炎症并伴有肉芽肿形成。他开始接受泼尼松治疗，并计划作为门诊病人开始使用免疫抑制剂。由于局灶性脑膜受累，韦格纳肉芽肿病可表现为多发性颅神经病1的临床表现。

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《The Internet Journal of Neurology》 |2008年第2期|共2页
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Max R. Lowden; Aiesha Ahmed;
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中图分类神经病学与精神病学;
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1. Severe localised granulomatosis with polyangiitis (Wegener’s granulomatosis) manifesting with extensive cranial nerve palsies and cranial diabetes insipidus: a case report and literature review [J] . James E. Peters, Vivek Gupta, Ibtisam T. Saeed, BMC Neurology . 2018,第1期

机译：严重的局部肉芽肿病伴多发性血管炎（韦格纳肉芽肿病），表现为广泛的颅神经麻痹和颅内尿崩症：一例病例并文献复习
2. Chronic meningitis with multiple cranial neuropathies: A rare initial presentation of Wegener's granulomatosis [J] . Vikas Gupta, Anjani Kumar Sharma, Rajendra Kumar Sureka, Annals of Indian Academy of Neurology . 2013,第3期

机译：慢性脑膜炎伴多发性颅神经病变：韦格纳肉芽肿病的罕见初步表现
3. Wegener's granulomatosis presenting with multiple cranial nerve palsies and pachymeningitis [J] . IqbalA.M., BlackburnD., RafiqM., Practical neurology . 2013,第3期

机译：韦格纳肉芽肿病伴多发性颅神经麻痹和脑膜炎
4. Induction of Apotosis of Human Endothelial Cells by Proteinase 3 (Pr3): A Possible Mechanism of Vascular Injury in Wegener's Granulomatosis [C] . M.E.J.Taekema-Roelvink, M.C. Janssens, E. Heemskerk, NATO Advanced Study Institute on Vascular Endothelium : Mechanisms of Cell Signaling . 1999

机译：蛋白酶3（PR3）诱导人内皮细胞的凋亡（PR3）：韦格纳粒细胞瘤病毒损伤的可能机制
5. Protein aggregation in peripheral myelin protein 22 (PMP22)-associated neuropathies. [D] . Fortun, Jenny. 2005

机译：外周髓磷脂蛋白22（PMP22）相关的神经病中的蛋白聚集。
6. Severe localised granulomatosis with polyangiitis (Wegener’s granulomatosis) manifesting with extensive cranial nerve palsies and cranial diabetes insipidus: a case report and literature review [O] . James E. Peters, Vivek Gupta, Ibtisam T. Saeed, 2018

机译：严重的局部肉芽肿合并多血管炎（韦格纳肉芽肿病）表现为广泛的颅神经麻痹和颅内尿崩症：一例病例并文献复习
7. Chronic meningitis with multiple cranial neuropathies: A rare initial presentation of Wegener′s granulomatosis [O] . Vikas Gupta, Anjani Kumar Sharma, Rajendra Kumar Sureka, 2013

机译：多发性颅神经病的慢性脑膜炎：韦格纳肉芽肿病的罕见初始表现

Wegener’s Granulomatosis presenting with multiple cranial neuropathies.

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