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首页> 外文期刊>The Internet Journal of Neurology >High-frequency Brain Oscillations (600 Hz) In Human Somatosensory Evoked Potentials - Quantification Of Effects After Needling And Stimulating Large Intestine 4 Using New EEG-electrodes
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High-frequency Brain Oscillations (600 Hz) In Human Somatosensory Evoked Potentials - Quantification Of Effects After Needling And Stimulating Large Intestine 4 Using New EEG-electrodes

机译：人体感觉诱发电位中的高频脑振荡（600 Hz）-使用新的EEG电极针刺和刺激大肠4后的效应量化

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High-frequency brain oscillations (600Hz) and conventional early somatosensory evoked potentials were investigated for the first time in 14 healthy volunteers (7 f, 7 m; mean age 22.7 + 3.3 years; range 19 - 32 years) during acupuncture at Large Intestine (LI-4, Hegu). Inserting the needles and manual stimulation produced significant (p < 0.05; Kruskal-Wallis ANOVA) decreases of amplitudes of 600Hz signals from generators located in the vicinity to the thalamus. Modulation of subcortical structures may be an important mechanism by which acupuncture exerts its complex effects. Introduction Human median nerve somatosensory evoked potentials (SEPs) contain an oscillatory burst of low-amplitude high-frequency (600Hz) wavelets superimposed on the N20 component.1 Acupuncture has been used to treat diseases for thousands of years in China. While some studies have shown that acupuncture could modify conventional SEPs 2,3 no study has been published on 600Hz brain oscillations and acupuncture. In the present study we report for the first time the effects of manual acupuncture and needle stimulation of acupoint LI-4 (Hegu) on high-frequency (600Hz) components in human SEPs using a new EEG recording technique. Methods Healthy VolunteersSEPs including 600Hz oscillations were investigated in 14 healthy volunteers. Seven persons were females and seven males. The mean age ± standard deviation was 22.7 ± 3.3 years (range 19 – 32 years). None had a history of psychiatric or neurological disorders or head trauma with loss of consciousness, or intake of tranquilizing drugs in the last 7 days. All healthy volunteer adults had some knowledge of acupuncture but had never received treatment. No subjects were in pain or distress at the time of the study. The study was approved by the ethics committee of the University of Graz and all subjects were paid and gave written informed consent. Stimulation, Recording and Evaluation ParametersThe elucidation of the SEPs was performed using peripheral electrical stimulation of the median nerve at the wrist of the right hand. The impulse duration was 0.2 ms, stimulus rate was 4.7 Hz, stimulus intensity was 3.0 – 9.2 mA and sampling frequency 10 kHz. Special adhesive electrodes (Nicolet, 019-768700) were used for stimulation. The distance between the anode and the cathode was 4.3 cm.SEPs and 600Hz oscillations were recorded using new active electroencephalographic electrodes 4,5.
机译：在大肠针灸期间，首次对14名健康志愿者（7 f，7 m;平均年龄22.7 + 3.3岁;范围19-32岁）进行了高频脑震荡（600Hz）和传统的早期体感诱发电位的研究。 LI-4，河谷）。插入针头和手动刺激产生了显着的（p <0.05; Kruskal-Wallis ANOVA），来自位于丘脑附近的发生器的600Hz信号的幅度减小了。皮层下结构的调节可能是针灸发挥其复杂作用的重要机制。引言人类中枢神经体感诱发电位（SEP）包含叠加在N20分量上的低振幅高频（600Hz）小波的振荡爆发。1在中国，针灸已被用于治疗疾病已有数千年的历史。尽管一些研究表明针灸可以改变常规的SEPs [2,3]，但尚未发表有关600Hz脑震荡和针灸的研究。在本研究中，我们首次使用新的EEG记录技术首次报告了人工针刺和针刺刺激穴位LI-4（Hegu）对人SEP中高频（600Hz）成分的影响。方法对14名健康志愿者进行包括600Hz振荡在内的健康志愿者SEPs的调查。七人为女性，七人为男性。平均年龄±标准差为22.7±3.3岁（范围19 – 32岁）。在过去的7天中，没有人有精神病或神经病史或因意识丧失而导致的头部外伤或服用安定药。所有健康的自愿成年人都有针灸知识，但从未接受过治疗。在研究时没有受试者感到疼痛或困扰。该研究得到格拉茨大学伦理委员会的批准，所有受试者均已付费并获得知情同意书。刺激，记录和评估参数使用右手腕部正中神经的周围电刺激来进行SEP的阐明。脉冲持续时间为0.2 ms，刺激速率为4.7 Hz，刺激强度为3.0 – 9.2 mA，采样频率为10 kHz。使用特殊的粘合电极（Nicolet，019-768700）进行刺激。阳极和阴极之间的距离为4.3 cm。使用新的有源脑电图电极4,5记录了SEP和600Hz振荡。

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