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首页> 外文期刊>Clinical neurophysiology >Are high-frequency (600Hz) oscillations in human somatosensory evoked potentials due to phase-resetting phenomena?
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Are high-frequency (600Hz) oscillations in human somatosensory evoked potentials due to phase-resetting phenomena?

机译：相变现象是否是人体感官诱发电位中的高频（600Hz）振荡？

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摘要

Objective: Median nerve somatosensory evoked potentials (SEP) contain a brief oscillatory wavelet burst at about 600. Hz (σ-burst) superimposed on the initial cortical component (N20). While invasive single-cell recordings suggested that this burst is generated by increased neuronal spiking activity in area 3b, recent non-invasive scalp recordings could not reveal concomitant single-trial added-activity, suggesting that the SEP burst might instead be generated by phase-reset of ongoing high-frequency EEG. Here, a statistical model and exemplary data are presented reconciling these seemingly contradictory results. Methods: A statistical model defined the conditions required to detect added-activity in a set of single-trial SEP. Its predictions were tested by analyzing human single-trial scalp SEP recorded with custom-made low-noise amplifiers. Results: The noise level in previous studies did not allow to detect single-trial added-activity in the period concomitant with the trial-averaged σ-burst. In contrast, optimized low-noise recordings do reveal added-activity in a set of single-trials. Conclusions: The experimental noise level is the decisive factor determining the detectability of added-activity in single-trials. A low-noise experiment provided direct evidence that the SEP σ-burst is at least partly generated by added-activity matching earlier invasive single-cell recordings. Significance: Quantitative criteria are provided for the feasibility of single-trial detectability of band-limited added-activity.
机译：目的：中枢神经体感诱发电位（SEP）包含一个短暂的振荡小波脉冲，其叠加在初始皮质成分（N20）上约600. Hz（σ-burst）。尽管有创性单细胞记录提示此爆发是由区域3b中神经元突触活动的增加引起的，但最近的非侵入性头皮记录无法揭示伴随的单次试验附加活性，这表明SEP猝发可能是由以下阶段引起的：重置正在进行的高频脑电图。在这里，提供了统计模型和示例性数据，以调和这些看似矛盾的结果。方法：一个统计模型定义了在一组单次试验SEP中检测添加活动所需的条件。通过分析用定制的低噪声放大器记录的人类单次试验头皮SEP检验了其预测。结果：以前的研究中的噪声水平不允许在与试验平均σ爆发相伴的时期内检测单次试验的添加活性。相比之下，经过优化的低噪声录音确实在一组单项试验中揭示了增加的活动性。结论：实验噪声水平是决定单项试验中添加活性可检测性的决定性因素。低噪声实验提供了直接证据，表明SEPσ爆发至少部分是由与早期侵入性单细胞记录相匹配的附加活性产生的。启示：提供了定量试验来确定带限添加活性的单次试验的可行性。

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