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首页> 外文期刊>The Internet Journal of Orthopedic Surgery >Assessment Of Renal Function In Pregnant Women Using Biochemical And Radiological Techniques In Nigeria.
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Assessment Of Renal Function In Pregnant Women Using Biochemical And Radiological Techniques In Nigeria.

机译：尼日利亚使用生化和放射技术评估孕妇肾功能。

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Background: Pregnancy is usually associated with increased vascular volume. This is usually considered physiologic rather than pathologic change because the condition easily resolves few minutes after delivery. Hypervolemic state will affect the concentrations of certain parameters thus reducing their usual predictive and diagnostic power. This work presents the findings of a study among women in a low resource setting in southeast Nigeria. The present study was designed to assess if the predictive and diagnostic powers of such biochemical parameters like serum urea, creatinine, uric acid, calcium and inorganic phosphate were compromised in pregnant women and possible diagnostic role. The use of ultrasonography may play in revealing the status of the kidney.Methodology: Thirty (30) pregnant women and twenty (20) non-pregnant women with no known history of renal problem were recruited for the present study. Blood samples were collected from all the participants and the serum components were extracted for the laboratory analyses of urea, creatinine, uric acid, calcium and inorganic phosphate while the ultrasound was used to obtain the ultrasonograhic status of the kidney, after obtaining an informed signed consent. Method for serum determination of urea was with diacetylmonoxine as modified by Wybenga (1971).Results: The findings showed no significant differences in mean (±SD), serum concentrations of urea; creatinine and uric acid between the pregnant woman and non-pregnant women (p>0.1 in each case). However, the ultra sonogram showed no difference in the mean parenchymal thickness of 1.9cm left and 1.91 ± 0.2cm3. Mean renal length is 80mm and this is not lower than was found in other studies of non-pregnant adult females.Conclusions: The use of serum urea and creatinine for kidney functional screening has gained a widespread acceptability amongst diagnostic experts. However, in cases where there has been a high suspicion of possible kidney functional impairment with inability of any of the usually used biochemical parameter to reveal same, radiological techniques may be used to further confirm such suspicion. The present design being a pilot study did not observe any loss in predictive and diagnostic ability of serum urea, creatinine and uric acid in screening for the kidney functional integrity in pregnant women. Since both the pregnant and non-pregnant women were apparently healthy, the finding in the present study suggest normal functional kidney despite the known hypervolemia usually reported in pregnant women. Ultrasound showed normal cortico-sinus differentiation in all the patients. Background Pregnancy is usually associated with increased vascular volume. This is usually considered physiologic rather than pathologic change because the condition easily resolves few minutes after delivery10. Hypervolemic state will affect the concentrations of certain parameters thus reducing their usual predictive and diagnostic power7. Therefore, it may not be proper in all cases to use references deduced from non-pregnant adults to infer in pregnant adult as this maybe misleading. Secondly, the use of radiological technique may help in determining the possible real state of certain organ function in pregnancy irrespective of hypervolemic state11. The present study was designed to assess if the predictive and diagnostic powers of such biochemical parameters like serum urea, creatinine, uric acid, calcium and inorganic phosphate were compromised in pregnant women and possible diagnostic role. The use of ultrasonography may play in revealing the status of the kidney. Methodology Subjects: Thirty (30) pregnant women and twenty (20) non-pregnant women with no known history of renal problem were recruited for the present study. They were aged between 20 and 45 years. Blood samples were collected from all the participants and the serum components were extracted for the laboratory analyses of urea, creatinine, uric acid, calcium and inorgani
机译：背景：怀孕通常与血管容量增加有关。通常认为这是生理性变化而不是病理性变化，因为这种情况在分娩后几分钟内很容易消失。高血容量状态会影响某些参数的浓度，从而降低其通常的预测和诊断能力。这项工作介绍了尼日利亚东南部资源匮乏地区妇女的一项研究结果。本研究旨在评估孕妇的血清尿素，肌酐，尿酸，钙和无机磷酸盐等生化参数的预测和诊断能力是否受到损害，并可能具有诊断作用。超声检查可能有助于揭示肾脏状况。方法：本研究招募了三十（30）名孕妇和二十（20）名无肾脏病史的非孕妇。收集所有参与者的血样，提取血清成分用于尿素，肌酐，尿酸，钙和无机磷酸盐的实验室分析，同时在获得知情同意的情况下，使用超声波获取肾脏的超声检查状态。尿素的血清测定方法是使用Wybenga（1971）修改的二乙酰基单抗。结果：结果显示，尿素的平均值（±SD），血清浓度无显着差异。孕妇和非孕妇之间的肌酐和尿酸（每种情况下p> 0.1）。然而，超声检查显示的平均实质壁厚分别为1.9cm和1.91±0.2cm3。平均肾脏长度为80mm，且不低于其他未怀孕成年女性研究的结论。结论：使用血清尿素和肌酐进行肾脏功能筛查已被诊断专家广泛接受。但是，如果高度怀疑可能的肾功能损害，而任何通常使用的生化参数都无法揭示该可能性，则可以使用放射学技术来进一步证实这种怀疑。本设计是一项初步研究，在筛查孕妇的肾功能完整性时，未发现血清尿素，肌酐和尿酸的预测和诊断能力有任何下降。由于孕妇和非孕妇都显然健康，因此本研究的结果表明尽管孕妇通常报告有已知的高血容量，但肾功能正常。超声显示所有患者的皮质窦窦分化正常。背景妊娠通常与血管容量增加有关。通常认为这是生理性变化而不是病理性变化，因为这种情况在分娩后几分钟内很容易消失。高血容量状态会影响某些参数的浓度，从而降低其通常的预测和诊断能力7。因此，可能并非在所有情况下都使用从非怀孕成年人中推断出的参考来推断怀孕成年人，因为这可能会引起误解。其次，放射技术的使用可能有助于确定妊娠中某些器官功能的可能真实状态，而与高血容量状态无关。本研究旨在评估孕妇的血清尿素，肌酐，尿酸，钙和无机磷酸盐等生化参数的预测和诊断能力是否受到损害，并可能具有诊断作用。超声检查可能有助于揭示肾脏状况。方法对象：招募了三十（30）名孕妇和二十（20）名无肾病史的未怀孕妇女进行本研究。他们的年龄在20至45岁之间。收集所有参与者的血样，提取血清成分，用于实验室分析尿素，肌酐，尿酸，钙和无机物。

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