Near infrared spectroscopy (NIRS) has been successfully used in this study to objectify cerebral alterations in oxyhemoglobin and desoxyhemoglobin, due to manual needle acupuncture and laserneedle acupuncture, in 88 healthy volunteers mean age 25.7 ± 4.0 ( x ± SD) years (19 - 38 years). Results from Traditional Chinese Acupuncture, Korean and Chinese hand acupuncture, ear acupuncture, combinations of the different acupuncture methods and placebo needling are presented. NIRS seems to be able to shed some light upon the functioning of the different acupuncture methods. Introduction The connection between puncturing the body with a needle and the reaction at another area of the body is still unclear. However, it has been proven that when particular acupuncture points are stimulated with needles or laser light, specific effects in the brain can be objectivized and quantified with modern cerebral monitoring methods [1,2,3]. In this present study, we objectivized the systematic changes of oxygenation in the brain [4] using cerebral near-infrared spectroscopy (NIRS), after stimulating acupuncture points according to Traditional Chinese Medicine (TCM), Korean and Chinese hand acupuncture, ear acupuncture and combinations of these different methods. We analyzed a total of 328 recordings after manual needle and laser needle stimulation from 88 healthy volunteers. Methods Near-infrared spectroscopyThe NIRS method allows the evaluation of changes in cerebral oxygenation through the intact skull and is also gaining importance in acupuncture research because of its non-invasive approach [4,5,6,7,8].The NIRO 300 Monitor (Hamamatsu Photonics, Japan) is a new instrument in this field of research. Parameters such as changes in oxyhemoglobin (ΔO2Hb) and desoxyhemoglobin (ΔHHb) are determined by Lambert-Beer′s principle [4]. The system can measure the absolute value (μmol) of changes in parameters, but not the level (absolute concentration) at which these changes occur (in positive or negative direction). The measurement value is zero, as long as no change in concentration occurs. Placement of the sensor (emitter and near-infrared detectors) on the head with a silicone holder is easy and reproducible. Data output of ΔO2Hb and ΔHHb were presented on a color LCD-Display and color printer.In addition to the spectroscopic method, non-invasive, standard monitoring parameters such as blood pressure (Cardiocap? CC-104, Datex Medical Electronics, Hoevelaken, Netherlands) were determined before, during and after different manners of stimulation.Laserneedle? stimulationThe Laserneedle?-technique represents a new, non-invasive method for optic stimulation of acupuncture points and was first described in literature in 2002 [9,10]. Laserneedle? (Schikora D.: European Patent Nr. PCT/EP 01/08504) acupuncture allows the simultaneous stimulation of individual acupuncture point combinations [9,10]. Variations and combinations of acupuncture at different areas of the body, ear or hand, as performed particularly in this study are possible (compare Fig. 1). Details regarding this method can be found in preceding studies [9,10].
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机译：近红外光谱（NIRS）已成功用于本研究中，以88例平均年龄25.7±4.0（x±SD）岁的健康志愿者为研究对象，归因于手动针刺和激光针刺导致的氧合血红蛋白和脱氧血红蛋白的脑部改变（19-38年份）。列出了中医针灸，韩中针灸，耳针，不同针刺方法和安慰剂针刺的结果。 NIRS似乎能够阐明不同针灸方法的功能。引言用针刺入身体与身体另一部位的反应之间的联系仍不清楚。但是，已经证明，当用针或激光刺激特定的穴位时，可以通过现代的大脑监测方法来客观化和量化大脑中的特定作用[1,2,3]。在本研究中，我们根据中药（TCM），韩中针灸，中医针刺，耳穴针刺和耳穴刺激刺激了穴位后，利用脑近红外光谱（NIRS）来客观化了大脑中氧合的系统变化[4]。这些不同方法的组合。我们分析了来自88位健康志愿者的人工针和激光针刺激后的328条记录。方法近红外光谱NIRS方法可通过完整的颅骨评估大脑氧合的变化，并且由于其非侵入性方法而在针灸研究中也变得越来越重要[4,5,6,7,8]。NIRO300 Monitor （日本Hamamatsu Photonics）是该研究领域中的一种新型仪器。氧合血红蛋白（ΔO2Hb）和脱氧血红蛋白（ΔHHb）的变化等参数是根据Lambert-Beer原理[4]确定的。系统可以测量参数变化的绝对值（μmol），但不能测量这些变化发生的水平（绝对浓度）（正向或负向）。只要浓度没有变化，测量值为零。使用硅胶支架将传感器（发射器和近红外检测器）放置在头部上很容易且可重复。 ΔO2Hb和ΔHHb的数据输出显示在彩色LCD显示器和彩色打印机上。除光谱法外，无创，标准的监测参数，例如血压（Cardiocap？CC-104，Datex Medical Electronics，Hoevelaken，荷兰） ）是在不同刺激方式之前，期间和之后确定的。 Laserneedle？技术代表了一种新的，非侵入性的方法来对穴位进行光学刺激，最早于2002年在文献中进行了描述[9,10]。激光针？ （Schikora D .：欧洲专利号PCT / EP 01/08504）针灸可以同时刺激各个穴位组合[9,10]。在这项研究中特别进行的针刺在身体，耳朵或手的不同区域的变化和组合都是可能的（比较图1）。有关此方法的详细信息可以在先前的研究中找到[9,10]。
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