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首页> 外文期刊>The Internet Journal of Asthma, Allergy and Immunology >Prevalence of specific aeroallergen sensitivity on skin prick test in patients with allergic rhinitis in Westchester County
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Prevalence of specific aeroallergen sensitivity on skin prick test in patients with allergic rhinitis in Westchester County

机译：威彻斯特县过敏性鼻炎患者对皮肤过敏试验的特异性空气过敏原敏感性患病率

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摘要

Allergic rhinitis is the most common cause of rhinitis, and is often the diagnosis prompting referral to the allergist for skin prick tests (SPT). The prevalence of positive SPT to different aeroallergens varies with the geographic setting. Westchester County is located in the state of New York, and there are no local data to date reflecting the prevalence of positive SPT. We therefore undertook a study to determine the reactivity to aeroallergens in the local population. The results of SPT to 48 aeroallergens and 2 controls were analyzed in 100 patients referred for allergic rhinitis. 65% had a positive SPT to at least 1 aeroallergen. Amongst the molds, alternaria positivity was noted in 8%, cat hair reacted in 18%, birch antigen was positive in 20% and reactivity to grass mix antigen was observed in 24%. The antigen showing the greatest SPT positivity was the house dust mite (30%). Sensitization rates for other antigens are presented. Background Allergic rhinitis is a highly prevalent allergen induced upper airway inflammatory disease, characterized by hyperreactive airway mucosa and episodes of acute exacerbation. 1 The incidence of upper respiratory allergy has increased since the past decade, posing a heavy burden on health care systems. 2 The skin prick test (SPT), is the most widely used allergy test, and can be performed during the initial consultation with a variety of allergens. 3 This study was undertaken to find the prevalence of skin test positivity to different aeroallergens in patients referred with allergic rhinitis in Westchester County. Methods A retrospective chart review was done on 100 consecutive patients referred to an ambulatory allergy office for symptoms of allergic rhinitis without asthma, during March 2006 to February 2007. Complete patient confidentiality was meticulously maintained. The results of skin puncture test to 48 different airborne allergens were analyzed. The allergens were divided into 4 groups. Group 1 included tree and leaf antigens, group 2 included grasses and weeds, group 3 constituted different molds, and group 4 antigens were of animal origin. A detailed history of symptoms and the presence of possible sources of allergens at home were taken. For skin puncture tests, Quintest ? multiple skin test system (Hollister-Stier Laboratories) was used. Normal saline and histamine served as negative and positive controls respectively. The skin prick testing device which comes in a kit, is made of molded plastic with 5 probes arranged linearly, each probe ending in a 1mm steel lancet tip that dip into a numbered reservoir containing a particular antigen. The allergens FAPP, HASH, and Special mold mix were obtained from ALK-Abelló, while all other allergens were obtained from Greer Laboratories. None of the patients were on any medications suppressing the immune system and all antihistaminics had been stopped 5 days prior to testing. The test area was cleaned with alcohol and allowed to dry. A Quintest ? test device was removed from a prepared tray containing the antigens, pressed down on the skin with medium pressure, and discarded. Subsequent testing sites were at least 3 cm apart from the initial test sites, to avoid the axon reflex. The results were read at 15 minutes, and a test site showing a wheal of 3 mm or more, and erythema of more than 10 mm was considered a positive reaction. 4 Dermatographism was excluded during the physical examination prior to SPT, and all patients included in the study had a positive histamine reaction. MS Excel was used as the graphing software. Results 100 patients, 48 males and 52 females, aged 6 – 83 years (mean age 40.92 years) were tested for skin prick test reactivity. The population included 68 whites, 11 blacks, 19 Hispanics and 2 patients of Asian origin. Amongst the 100 patients tested, 65 patients had a positive test to at least 1 aeroallergen. Of these 65 patients, 42 white (61.7%), 14 Hispanic (73.6%) and 9 black (72.7%) had positive SPT.
机译：变应性鼻炎是鼻炎的最常见原因，通常是诊断提示，请转诊至变应性过敏者进行皮肤点刺试验（SPT）。阳性SPT对不同的空气过敏原的患病率随地理位置而异。威彻斯特县（Westchester County）位于纽约州，迄今为止，尚无本地数据反映阳性SPT的流行。因此，我们进行了一项研究，以确定在当地人口中与空气过敏原的反应性。分析了100例过敏性鼻炎患者中SPT对48种气敏性变应原和2个对照的结果。 65％的SPT对至少1种气敏原呈阳性。在霉菌中，交链菌阳性率为8％，猫毛反应为18％，桦木抗原为阳性，为20％，与草混合抗原的反应性为24％。 SPT阳性率最高的抗原是屋尘螨（30％）。给出了其他抗原的敏化率。背景变应性鼻炎是一种高度流行的变应原诱发的上呼吸道炎性疾病，其特征是气道黏膜反应过度和急性发作。 1自上个十年以来，上呼吸道过敏的发生率有所增加，给医疗保健系统造成了沉重负担。 2皮肤点刺测试（SPT）是使用最广泛的变态反应测试，可以在初诊期间使用多种变应原进行。 3进行这项研究的目的是为了发现在韦斯特切斯特县接受过敏性鼻炎治疗的患者中，皮肤测试对不同的气敏原的阳性率。方法2006年3月至2007年2月，对100例因非哮喘性变应性鼻炎症状而转诊至门诊变态反应室的连续患者进行回顾性回顾。对患者的完全保密进行了严格的保密。分析了48种空气传播的过敏原的皮肤穿刺测试结果。过敏原分为4组。第一组包括树木和叶子的抗原，第二组包括草和杂草，第三组构成不同的霉菌，第四组抗原是动物来源的。记录详细的症状史和在家中可能的过敏原来源。对于皮肤穿刺测试，Quintest？使用了多种皮肤测试系统（Hollister-Stier Laboratories）。生理盐水和组胺分别作为阴性和阳性对照。套件中的皮肤点刺测试设备由模制塑料制成，带有5个线性排列的探针，每个探针末端都在一个1mm的刺血针尖端中，该尖端刺入包含特定抗原的编号储存器中。过敏原FAPP，HASH和特殊模具混合物来自ALK-Abelló，而所有其他过敏原则来自Greer Laboratories。所有患者均未使用任何抑制免疫系统的药物，并且所有抗组胺药已在测试前5天停药。用酒精清洁测试区域并使其干燥。 Quintest？从准备好的含有抗原的托盘中取出测试装置，在中等压力下将其压在皮肤上，并丢弃。随后的测试部位与初始测试部位至少相距3 cm，以避免轴突反射。在15分钟时读取结果，并且测试部位显示出3mm或更大的风团，并且10mm以上的红斑被认为是阳性反应。 4在SPT之前的体格检查期间皮肤镜检查被排除在外，并且研究中所有患者的组胺反应均为阳性。 MS Excel被用作绘图软件。结果对100例患者进行了皮刺反应性测试，其中男48例，女52例，年龄6至83岁（平均年龄40.92岁）。人口包括68位白人，11位黑人，19位西班牙裔美国人和2位亚洲裔患者。在接受测试的100名患者中，有65名患者的至少1种空气过敏原呈阳性。在这65名患者中，有42名白人（61.7％），14名西班牙裔（73.6％）和9名黑人（72.7％）的SPT阳性。

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