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首页> 外文期刊>The Journal of Musculoskeletal and Neuronal Interactions >Osteocyte biology: Its implications for osteoporosis
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Osteocyte biology: Its implications for osteoporosis

机译：骨细胞生物学：对骨质疏松症的影响

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摘要

Osteocyte viability may play a significant role in the maintenance and integrity of bone. Bone loss due to osteoporosis may be due in part to osteocyte cell death. We have identified a factor that will protect both osteoblasts and osteocytes from cell death due to agents known to be responsible for various forms of osteoporosis. Not only does estrogen preserve osteoblast and osteocyte viability, but so does a molecule called CD40Ligand. This molecule is expressed on activated T lymphocytes, human dendritic cells, and human vascular endothelial cells, whereas its receptor CD40 is expressed on normal epithelium, B cells, and dendritic cells. CD40Ligand protects osteoblasts and the MLO-Y4 osteocyte-like cells against apoptosis induced by glucocorticoids, tumor necrosis factor · or etoposide. As tumor necrosis factor a has been shown to be responsible for postmenopausal bone loss and glucocorticoids induce dramatic bone loss, this finding has important implications with regards to potential therapy for both post-menopausal and steroid-induced osteoporosis.
机译：骨细胞的生存能力可能在骨骼的维持和完整性中起重要作用。骨质疏松引起的骨质流失可能部分是由于骨细胞死亡。我们已经确定了一种因素，该因素可以保护成骨细胞和骨细胞免受因已知导致多种形式的骨质疏松症的病因而导致的细胞死亡。雌激素不仅可以保持成骨细胞和骨细胞的活力，而且还可以保护称为CD40Ligand的分子。该分子在活化的T淋巴细胞，人树突状细胞和人血管内皮细胞上表达，而其受体CD40在正常上皮，B细胞和树突状细胞上表达。 CD40Ligand保护成骨细胞和MLO-Y4骨细胞样细胞免受糖皮质激素，肿瘤坏死因子或依托泊苷的诱导凋亡。由于已经证明肿瘤坏死因子α是导致绝经后骨质流失的原因，而糖皮质激素导致了严重的骨质流失，这一发现对于绝经后和类固醇引起的骨质疏松症的潜在治疗具有重要意义。

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