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首页> 外文期刊>The Internet Journal of Tropical Medicine >Summary On The Prevalence Of Serum VCA-IgA Antibody Among Thai Patients With Lymphoma: An Implication For Risk And Screening Purpose
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Summary On The Prevalence Of Serum VCA-IgA Antibody Among Thai Patients With Lymphoma: An Implication For Risk And Screening Purpose

机译：泰国淋巴瘤患者血清VCA-IgA抗体患病率的总结：风险和筛查目的

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摘要

Lymphoma is a common hematological malignancy. Relationship with the Epstein-Barr virus (EBV) was indicated. Anti-EBV serology, immunoligcal test for detection of EBV infection is applied for screening and detection of lymphoma. Of several tests, lgA antibody to viral capsid antigens of Epstein-Barr virus (VCA-lgA antibody) has been mentioned as a valuable test for screening for and early detection of lymphoma. Here, the author performs an appraisal on the prevalence of serum VCA-lgA antibody among Thai patients with lymphoma comparing with healthy control subjects. According to the literature review, 2 reports [6, 7] were recruited for further metanalysis. According to the metanalysis, 39 cases and 252 healthy subjects were investigated for serum VCA-lgA antibody. The overall antibody positive rate in the patients and healthy subjects are 35.9 % (14/39) and 2.4 % (6/252), respectively. The odds ratio is 22.96. According to this study, it could be seen that having serum VCA-lgA antibody positive is a very high risk for lymphoma. Of interest, although the lymphoma is high prevalent in Thailand there is no specific recommendation in screening for this disease in high risk population. According to this study, the results suggested that the EBV-specific serum IgA antibodies might be a useful screening test for the cancer in people of high risk. Introduction Lymphoma is a common hematological malignancy. Relationship with the Epstein-Barr virus (EBV) was indicated [1]. Young and Rickinson said that EBV was found to be widespread in all human populations and to persist in the vast majority of individuals as a lifelong, asymptomatic infection of the B-lymphocyte poo [1]. They noted that despite such ubiquity, the link between EBV and endemic lymphoma proved consistent and became the first of an unexpectedly wide range of associations discovered between this virus and tumors [1]. Concerning the correlation between tumor and EBV, Busson et al recently said that tumor development appeared to require the expression of a small subset of transforming viral RNAs [2]. They also noted that Impairment of the interactions of viral proteins with cellular partners or disruption of viral latency might prove to be useful for novel therapeutic strategies [2]. Anti-EBV serology, immunoligcal test for detection of EBV infection is applied for screening and detection of many EBV – related cancers including lymphoma [3]. However, the detection of Anti-EBV IgG is not useful in some specific area such as the tropical Southeast Asia where most of the populations usually have positive titer for this antibody [4]. Therefore, new more specific Anti-EBV tests are required. Of several tests, IgA antibody to viral capsid antigens of EBV (VCA-lgA antibody) has been mentioned as a valuable test for screening for and early detection of lymphoma [5,6, 7]. Here, the author performs an appraisal on the prevalence of serum VCA-lgA antibody among Thai patients with lymphoma comparing with healthy control subjects. Risk analysis was performed. The author hypothesized that the serum VCA-lgA antibody might be an effective screening test for lymphoma among the Thais. Materials and Methods Literature reviewA literature review to find the previous reports about prevalence of serum VCA-lgA antibody among patients with lymphoma and healthy control subjects in Thailand was performed. The author used the electronic search engine PubMed (www.pubmed.com) in searching for the literatures. The author also reviewed the published works in all 256 local Thai journals, which is not included in the international citation index by the database Thai Index Medicus. Any report that did not present the prevalence in both patients with lymphoma and healthy control subjects were excluded. MetanalysisThe available reports were collected and extracted for the data about the prevalence of serum VCA-lgA antibody. Those primary data were used for further metanalysis study. Concerning the metanalysis
机译：淋巴瘤是常见的血液系统恶性肿瘤。表明与爱泼斯坦巴尔病毒（EBV）的关系。用于检测EBV感染的抗EBV血清学，免疫胶凝试验可用于淋巴瘤的筛查和检测。在几种测试中，已经提到了针对爱泼斯坦-巴尔病毒的衣壳抗原的lgA抗体（VCA-lgA抗体），作为筛选和早期发现淋巴瘤的有价值的测试。在此，作者对泰国淋巴瘤患者与健康对照者的血清VCA-lgA抗体患病率进行了评估。根据文献综述，招募了2篇报告[6，7]进行进一步的荟萃分析。根据荟萃分析，对39例和252名健康受试者的血清VCA-IgA抗体进行了调查。患者和健康受试者的总体抗体阳性率分别为35.9％（14/39）和2.4％（6/252）。比值比是22.96。根据这项研究，可以看出，血清VCA-IgA抗体呈阳性是淋巴瘤的极高风险。有趣的是，尽管淋巴瘤在泰国非常流行，但在高危人群中筛查该病并没有特别推荐。根据这项研究，结果表明，EBV特异性血清IgA抗体可能是对高危人群的癌症有用的筛选测试。引言淋巴瘤是一种常见的血液系统恶性肿瘤。指出与爱泼斯坦-巴尔病毒（EBV）的关系[1]。 Young和Rickinson表示，EBV被发现是B淋巴细胞poo的终生无症状感染，并在绝大多数人群中持续存在[1]。他们指出，尽管无处不在，但EBV与地方性淋巴瘤之间的联系被证明是一致的，并成为该病毒与肿瘤之间出乎意料的广泛关联中的第一个[1]。关于肿瘤和EBV之间的相关性，Busson等人最近说，肿瘤的发展似乎需要表达一小部分转化病毒RNA [2]。他们还指出，病毒蛋白与细胞伴侣的相互作用减弱或病毒潜伏期的破坏可能对新型治疗策略很有用[2]。抗EBV血清学，用于检测EBV感染的免疫胶凝试验可用于筛查和检测许多与EBV相关的癌症，包括淋巴瘤[3]。但是，抗EBV IgG的检测在某些特定区域没有用处，例如热带东南亚，其中大多数人群通常对该抗体具有阳性滴度[4]。因此，需要新的更具体的抗EBV测试。在几种测试中，已经提到了针对EBV病毒衣壳抗原的IgA抗体（VCA-IgA抗体），作为筛查和早期发现淋巴瘤的有价值的测试[5,6,7]。在此，作者对泰国淋巴瘤患者与健康对照者的血清VCA-lgA抗体患病率进行了评估。进行了风险分析。作者假设血清VCA-IgA抗体可能是泰国人中淋巴瘤的有效筛查方法。材料和方法文献综述进行文献综述，以寻找先前有关泰国淋巴瘤患者和健康对照对象中血清VCA-lgA抗体患病率的报道。作者使用电子搜索引擎PubMed（www.pubmed.com）来搜索文献。作者还审查了全部256种泰国当地期刊中的已发表著作，但该数据库未包含在Thai Thai Medicus数据库的国际引文索引中。排除任何在淋巴瘤患者和健康对照者中均无患病率的报告。荟萃分析收集和提取可用的报告以获取有关血清VCA-IgA抗体患病率的数据。这些原始数据用于进一步的荟萃分析研究。关于荟萃分析

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