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首页> 外文期刊>The Internet Journal of Toxicology >High Cholesterol Levels And Chronic Exposure To Toxigenic Molds In Damp Buildings: A High Risk For Cardiovascular Diseases And Stroke
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High Cholesterol Levels And Chronic Exposure To Toxigenic Molds In Damp Buildings: A High Risk For Cardiovascular Diseases And Stroke

机译：高胆固醇水平和长期暴露于潮湿建筑的产毒霉菌中：心血管疾病和中风的高风险

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Epidemiological evidence suggests a possible association between chronic exposures to toxigenic molds in damp water-damaged buildings and high levels of cholesterol abnormalities that may represent a high risk for cardiovascular diseases. Although, cholesterol has many useful functions in the body, including its role in membrane structure, brain tissue, fetal development and the biosynthesis of other steroidal hormones, its harmful effects in the body have been widely publicized. Although, the physiological status of cholesterol in animals exposed to toxigenic molds have been reported, there is not enough experimental evidence to support similar occurrence in humans. The purpose of this review is to provide a basis for discussion in the light of on-going research on the topic.The effects of chronic toxigenic mold exposures on individuals in damp buildings are reviewed to provide the background for better understanding of their associations with the observed cholesterol abnormalities. The structure, and the regulatory mechanisms of cholesterol biosynthesis are assessed to identify the important enzymes interact with the toxigenic molds and mycotoxins to which abnormalities are enhanced. It was for this purpose that the effects of mycotoxins on metabolism, cellular supply and utilization of cholesterol and bile acid synthesis and related cardiovascular disease symptomology are evaluated. The outcomes of the reviews showed that, persons exposed to chronic toxigenic molds in damp buildings might be at risk of cardiovascular diseases and other related disorders. This assumption was based on the structural and functional activities highlighted by the evidence from animal models of cholesterolemia: cholesterol LDL-cholesterol/depression, atherosclerosis, premature coronary artery disease (CAD) and neurogenetic aspects of hypercholesterolemia. Given the fact that toxigenic molds release mycotoxins that affect human health, and given the possibility that structurally, and mechanistically, mycotoxins could adversely affect cholesterol metabolism through interactions with the related enzymes and disruption of cellular supply and utilization of cholesterol, and bile acid synthesis, it is most likely that individuals exposed to chronic toxigenic molds might be at risk of neurological disorders including cardiovascular diseases and stroke.
机译：流行病学证据表明，在潮湿的水源损坏的建筑物中长期暴露于产毒霉菌与高水平的胆固醇异常（可能代表心血管疾病的高风险）之间可能存在关联。尽管胆固醇在体内具有许多有用的功能，包括其在膜结构，脑组织，胎儿发育和其他甾体激素的生物合成中的作用，但其在体内的有害作用已广为人知。尽管已经报道了暴露于产毒霉菌的动物体内胆固醇的生理状态，但没有足够的实验证据来支持人类中类似的发生。这篇综述的目的是根据有关该主题的持续研究为讨论提供基础。综述了慢性毒物霉菌暴露对潮湿建筑物中个体的影响，以提供背景以更好地了解他们与湿气建筑的关联。观察胆固醇异常。评估胆固醇生物合成的结构和调控机制，以鉴定与异常性增强的产毒霉菌和霉菌毒素相互作用的重要酶。出于此目的，评估了霉菌毒素对代谢，胆固醇的细胞供应和利用以及胆汁酸合成以及相关心血管疾病症状的影响。审查结果表明，在潮湿的建筑物中暴露于慢性产毒霉菌的人可能有患心血管疾病和其他相关疾病的风险。该假设基于胆固醇血症动物模型证据所强调的结构和功能活动：胆固醇低密度脂蛋白胆固醇/抑郁症，动脉粥样硬化，早发冠状动脉疾病（CAD）和高胆固醇血症的神经遗传学方面。鉴于有毒的霉菌会释放出影响人体健康的霉菌毒素，并考虑到霉菌毒素在结构上和机理上可能会通过与相关酶的相互作用，破坏胆固醇的细胞供应和利用以及胆汁酸的合成而对胆固醇代谢产生不利影响，暴露于慢性产毒霉菌的个体最有可能面临神经系统疾病（包括心血管疾病和中风）的风险。

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