• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Internet journal of veterinary medicine >Scapular osteosarcoma in a 14-Month-Old Golden Retriever
【24h】

Scapular osteosarcoma in a 14-Month-Old Golden Retriever

机译：14个月大的黄金猎犬的肩cap骨肉瘤

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A 14-month-old golden retriever was presented with progressive right front limb lameness of 1.5 months' duration caused by a large spherical mass in the right scapula. Radiographic examination was consistent with skeletal neoplasia, showing a distinctive area of osteolytic and osteogenic activity, adjacent soft tissue invasion and metastatic lesions in the anterior lung fields. The histopathologic examination established the diagnosis of minimally productive, osteoblastic, grade III osteosarcoma. Both scapular osteosarcomas and osteosarcomas in very young dogs are rarely described; to the best of our knowledge, scapular osteosarcomas have not been described at such a young age previously. Introduction Osteosarcoma (OS) is the most common primary bone tumour in the dog. In general, it is an aggressive malignancy of osteoblasts with a high rate of metastasis. 5,18,20 According to the World Health Organization classification of bone and joint tumors, 17 an OS is a primary malignant neoplasm of mesenchymal origin that gives rise to a variety of patterns but always includes the production of bone by malignant osteoblasts. Its biological behaviour seems to vary depending on location, age or breed. 5,18,20 Although there is a broad range in the age of onset, OS is a disease that mostly occurs in middle-aged to older dogs, with a median age of 7 years. 2,5,18,20 The metaphyseal region of the long bones is the most common primary site. 5,18,20 This paper reports a case of a scapular osteosarcoma in a 14-month old dog, thus presenting a case that has arisen both in an uncommon location and in an uncommonly young age. Case Report A 14 month-old, male entire, golden retriever weighing 25 kg was presented to a private clinic in Limassol, Cyprus with a history of progressive right forelimb lameness of 1.5 months' duration. Upon clinical examination, a large, spherical mass, measuring approximately 30 cm in diameter, concerning the right scapula as well as generalized muscle atrophy of the limb were observed. On palpation, the mass was hard, poorly demarcated, solid, and had irregular and rough surface, while the shoulder was painful when passively pulled. The dog was alert but its temperature was remarkably high (40.7 C). Additionally, mild coughing was easily reproduced during light exercise and exposure to stress, and mild abnormal sounds in the lung were noticed during thorax auscultation.Complete blood count, biochemistry profile and urinalysis were unremarkable apart from indicating mild nonregenerative anemia probably due to the chronic nature of the disease. Our initial diagnostic considerations included two main differentials: skeletal neoplasia and granuloma caused by chronic inflammation.The dog was hospitalized and treated with amoxicillin - clavulanate a (Synulox original, Pfizer Hellas A.E., 0.05 ml/Kg s.c. SID) as well as carprofen b (Rimandyl, Pfizer Hellas A.E. 0.085 ml/kg s.c. SID) for 10 days. At the end of the treatment the dog's temperature and appetite returned to normal. On radiographic examination both the right lateral (Figure 1A) and the dorsoventral (Figure 1B) view of the front limb showed a distinctive area of osteolytic and osteogenic activity within the scapula. New bone formation extended in a palisading (or so-called sunburst) pattern radiating from the adjacent normal bone, while the surrounding soft tissues appeared swollen.
机译：出现了一个14个月大的金毛寻回犬，由于右肩spherical骨上有较大的球形团块而导致进行时间为1.5个月的右前肢la行。影像学检查与骨骼肿瘤一致，显示出独特的溶骨和成骨活性区域，邻近的软组织浸润以及前肺野中的转移性病变。组织病理学检查确定了最低生产力的成骨细胞III级骨肉瘤的诊断。很少描述幼犬的肩骨肉瘤和骨肉瘤。据我们所知，肩such骨肉瘤在这么小的年龄之前还没有被描述过。简介骨肉瘤（OS）是狗中最常见的原发性骨肿瘤。通常，它是具有高转移率的成骨细胞的恶性肿瘤。 5,18,20根据世界卫生组织对骨和关节肿瘤的分类，17 OS是间充质来源的原发性恶性肿瘤，其产生多种模式，但始终包括恶性成骨细胞产生的骨。它的生物学行为似乎取决于位置，年龄或品种。 5,18,20尽管发病年龄范围很广，但OS是一种疾病，多发于中年至老年狗，中位年龄为7岁。 2,5,18,20长骨的干phy端区域是最常见的主要部位。 5,18,20本文报道了在一个14个月大的狗中出现肩骨肉瘤的病例，因此，该病例既出现在罕见的位置，也出现在罕见的年轻年龄。病例报告一名14个月大，重25公斤的雄性全金毛寻回犬被送至塞浦路斯利马索尔的一家私人诊所，该病的病程为进行性前肢la行，病程为1.5个月。经过临床检查，观察到一个大的球形肿块，直径约30厘米，涉及右肩cap骨以及四肢的全身性肌肉萎缩。触诊时，肿块变硬，分界差，结实，表面不规则且粗糙，而被动牵拉时肩膀疼痛。这只狗机敏，但体温非常高（40.7摄氏度）。此外，轻度运动和暴露于压力下很容易产生轻度咳嗽，在胸腔听诊时发现肺部轻度异常声音，除了表明轻度非再生性贫血外，全血细胞计数，生化特征和尿液分析无明显异常，可能是由于慢性所致这种疾病。我们最初的诊断考虑因素包括两个主要区别：骨骼炎症和慢性炎症引起的肉芽肿。该犬住院并接受阿莫西林-克拉维酸a（Synulox原始，辉瑞Hellas AE，0.05 ml / Kg sc SID）和卡洛芬b（ Rimandyl，辉瑞Hellas AE（0.085 ml / kg sc SID），持续10天。治疗结束后，狗的体温和食欲恢复正常。放射学检查前肢的右外侧（图1A）和背腹（图1B）视图均显示肩the骨内有独特的溶骨和成骨活性区域。新的骨形成以相邻的正常骨​​放射出的苍白（或所谓的朝阳）图案扩展，而周围的软组织则肿胀。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号